Connecticut Sinus Institute, University of Connecticut, Farmington, Connecticut, USA.
Otolaryngol Head Neck Surg. 2012 Mar;146(3):483-6. doi: 10.1177/0194599811427660. Epub 2011 Nov 2.
Sinonasal hemangiopericytomas (SNHPCs) are rare perivascular tumors with low-grade malignant potential. Traditionally, these tumors have been treated with open approaches such as lateral rhinotomy, Caldwell-Luc, or transfacial approaches. Increased experience with endoscopic management of benign and malignant sinonasal tumors has led to a shift in management of SNHPC. The authors present their experience in the largest series of patients with SNHPC managed endoscopically.
Case series at a tertiary care medical center.
A retrospective chart review of all patients undergoing endoscopic management of SNHPC at the University of Miami between 1999 and 2008 was conducted. All endoscopic resections were performed with curative intent.
Twelve patients with the diagnosis of SNHPC were treated endoscopically. Mean age was 62.5 years (range, 51-83 years). There were 6 men and 6 women. The mean follow-up was 41 months (range, 15-91 months). Seven (58.3%) presented with nasal obstruction, whereas 4 (41.6%) had epistaxis as their initial presenting symptom. Preoperative angiography or embolization was not performed in any case. Mean estimated blood loss was 630 mL (range, 100-1500 mL). Six patients underwent endonasal endoscopic anterior skull base resection; 4 had complete endoscopic resection all with negative margins. None underwent postoperative adjuvant treatment. No recurrence or metastatic disease was observed in this patient population.
Endoscopic management of SNHPC is a feasible approach and did not compromise outcomes in this experience. In this series, familiarity with advance endoscopic sinus surgery was necessary to manage these patients. Postoperative adjuvant therapy was not necessary in this cohort.
鼻窦血管外皮细胞瘤(SNHPC)是一种罕见的具有低度恶性潜能的血管周围肿瘤。传统上,这些肿瘤采用开放式方法治疗,如外侧鼻切开术、Caldwell-Luc 或经面入路。由于内镜治疗良性和恶性鼻窦肿瘤的经验增加,SNHPC 的治疗方式也发生了转变。作者报告了他们在最大系列接受内镜治疗的 SNHPC 患者中的经验。
三级医疗中心的病例系列。
对 1999 年至 2008 年间在迈阿密大学接受内镜治疗 SNHPC 的所有患者的病历进行回顾性图表审查。所有内镜切除术均以治愈为目的进行。
12 例患者被诊断为 SNHPC,接受了内镜治疗。平均年龄为 62.5 岁(范围,51-83 岁)。男性 6 例,女性 6 例。平均随访时间为 41 个月(范围,15-91 个月)。7 例(58.3%)以鼻塞为首发症状,而 4 例(41.6%)以鼻出血为首发症状。在任何情况下均未进行术前血管造影或栓塞。平均估计失血量为 630 毫升(范围,100-1500 毫升)。6 例患者接受了经鼻内镜前颅底切除术;4 例患者完全内镜切除,均切缘阴性。术后均未接受辅助治疗。在该患者人群中未观察到复发或转移疾病。
SNHPC 的内镜治疗是一种可行的方法,在本研究中并未影响治疗效果。在本系列中,需要熟悉先进的内镜鼻窦手术才能对这些患者进行治疗。在该队列中,术后辅助治疗不是必需的。