Tanagho E A
Department of Urology, University of California School of Medicine, San Francisco.
Urologe A. 1990 Jul;29(4):185-90.
Neurostimulation to restore the essential elements of lower urinary tract function is a very promising approach in the management of the neuropathic bladder. The goal of neurostimulation is to restore the three main functions of the lower urinary tract: the reservior capacity of the bladder, the sphincteric activity of the continence mechanism, and the ability of the bladder to evacuate completely. In extensive experimental studies conducted over the past 18 years, the physiological foundations of micturition and sphincteric control were investigated, which made the clinical application of neurostimulation in the management of the neurogenic bladder possible. In human studies, the essential experimental model of ventral root stimulation after dorsal rhizotomy and selective peripheral neurotomy proved to be the most successful. To date, over 220 patients have been treated, of whom 35 have spinal cord injury or severe neuropathy and received multiple sacral root implants. 25 of the 35 patients are evaluable, 15 (60%) of these achieved the three goals of the study: complete continence, restoration of reservoir function with adequate capacity, and voiding to neurostimulation with minimal residual urine or none. The remaining 185 patients with a variety of voiding dysfunctions classified under four main headings: 1) urge incontinence; 2) post-prostatectomy incontinence; 3) pelvic dysfunction syndrome in the male; 4) pelvic dysfunction syndrome in the female were treated by single electrode implantation in order to modulate spastic voiding dysfunction and pelvic floor activity. Success rates (improvement of 50% or more) were 72%, 38%, 46%, and 47% in the four groups, respectively.
神经刺激以恢复下尿路功能的基本要素是治疗神经源性膀胱的一种非常有前景的方法。神经刺激的目标是恢复下尿路的三个主要功能:膀胱的储尿能力、控尿机制的括约肌活动以及膀胱完全排空的能力。在过去18年进行的广泛实验研究中,对排尿和括约肌控制的生理基础进行了研究,这使得神经刺激在神经源性膀胱治疗中的临床应用成为可能。在人体研究中,背根切断术后腹侧神经根刺激和选择性周围神经切断术的基本实验模型被证明是最成功的。迄今为止,已治疗了220多名患者,其中35人患有脊髓损伤或严重神经病变,并接受了多个骶神经根植入。35名患者中有25名可进行评估,其中15名(60%)实现了研究的三个目标:完全控尿、恢复具有足够容量的储尿功能以及通过神经刺激排尿且残余尿量最少或无残余尿。其余185名患有各种排尿功能障碍的患者分为四个主要类别:1)急迫性尿失禁;2)前列腺切除术后尿失禁;3)男性盆底功能障碍综合征;4)女性盆底功能障碍综合征,通过单电极植入进行治疗,以调节痉挛性排尿功能障碍和盆底活动。四组的成功率(改善50%或更多)分别为72%、38%、46%和47%。