Division of Hematology, Department of Medicine Department of Oncology Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Br J Haematol. 2012 Jan;156(2):173-85. doi: 10.1111/j.1365-2141.2011.08920.x. Epub 2011 Nov 3.
Developed countries, such as the United Kingdom, are experiencing a change in demographics resulting in the largest proportion of adults over 65 years of age that our health systems have ever experienced. As such, haematologists must be prepared to evaluate and treat anaemia in a more complicated patient population, but sufficient evidence-based guidelines are lacking. Critical next steps that must be taken to ensure the best care of this population include the determination of appropriate haemoglobin concentrations for older adults in light of age, gender, race, and comorbidities; the development of interventional trials that address physical performance outcomes in addition to haemoglobin targets; and translational studies which address the molecular pathogenesis of anaemia in older adults with the most advanced scientific approaches.
发达国家,如英国,正在经历人口结构的变化,导致 65 岁以上成年人的比例达到了我们的卫生系统从未经历过的水平。因此,血液学家必须准备好评估和治疗更为复杂的患者人群的贫血症,但缺乏充分的循证指南。为确保为这一人群提供最佳护理,必须采取的关键下一步包括根据年龄、性别、种族和合并症确定老年人的适当血红蛋白浓度;开展干预试验,除了血红蛋白目标外,还要解决身体表现结果;以及应用最先进的科学方法进行针对老年人贫血症分子发病机制的转化研究。