Moritz M W, Higgins R F, Jacobs J R
Department of Surgery, Wayne State University, Detroit, Mich.
Arch Surg. 1990 Sep;125(9):1181-3. doi: 10.1001/archsurg.1990.01410210107017.
Radiation-induced carotid artery disease following high-dose (greater than 50-Gy) radiotherapy for head and neck cancer may become more common as improved treatment results in longer survival. Duplex ultrasound scans were obtained in 91 consecutive patients to determine whether increased incidence and severity of extracranial carotid disease correlate with prior radiotherapy. Fifty-three patients who underwent radiotherapy an average of 28 months previously and 38 patients who received no radiotherapy were studied. Thirty percent of the irradiated group had lesions of the carotid arteries that were either moderate or severe vs only 6% of the control patients. Five patients were symptomatic; all had undergone radiotherapy. Long-term follow-up with sequential duplex ultrasound examinations is indicated in patients receiving high-dose radiotherapy for head and neck tumors, to detect radiation-induced carotid artery disease and prevent late sequelae.
随着头颈部癌高剂量（大于50戈瑞）放疗后治疗效果改善使患者生存期延长，放射性颈动脉疾病可能会变得更加常见。对91例连续患者进行了双功超声扫描，以确定颅外颈动脉疾病发病率和严重程度的增加是否与既往放疗相关。研究了平均在28个月前接受放疗的53例患者和未接受放疗的38例患者。放疗组中30%的患者有中度或重度颈动脉病变，而对照组患者仅为6%。5例患者出现症状；所有患者均接受过放疗。对头颈部肿瘤接受高剂量放疗的患者，建议进行连续双功超声检查的长期随访，以检测放射性颈动脉疾病并预防晚期后遗症。
