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与头颈部癌症相关的新型变异的基因-环境相互作用。

Gene-environment interactions of novel variants associated with head and neck cancer.

机构信息

Department of Community Health, Brown University, Providence, Rhode Island, USA.

出版信息

Head Neck. 2012 Aug;34(8):1111-8. doi: 10.1002/hed.21867. Epub 2011 Nov 2.

DOI:10.1002/hed.21867
PMID:22052802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3662053/
Abstract

BACKGROUND

A genome-wide association study for upper aerodigestive tract cancers identified 19 candidate single-nucleotide polymorphisms (SNPs). We used these SNPs to investigate the potential gene-gene and gene-environment interactions in head and neck squamous cell carcinoma (HNSCC) risk.

METHODS

The 19 variants were genotyped using Taqman assays among 575 cases and 676 controls in our population-based case-control study.

RESULTS

A restricted cubic spline model suggested both ADH1B and HEL308 modified the association between smoking pack-years and HNSCC. Classification and regression tree analysis demonstrated a higher-order interaction between smoking status, ADH1B, FLJ13089, and FLJ35784 in HNSCC risk. Compared with ever smokers carrying ADH1B T/C+T/T genotypes, smokers carrying ADH1B C/C genotype and FLJ13089 A/G+A/A genotypes had the highest risk of HNSCC (odds ratio = 1.84).

CONCLUSIONS

Our results suggest that the risk associated with these variants may be specifically important among specific exposure groups.

摘要

背景

一项针对上呼吸道和消化道癌症的全基因组关联研究确定了 19 个候选单核苷酸多态性（SNP）。我们使用这些 SNP 来研究头颈部鳞状细胞癌（HNSCC）风险中的潜在基因-基因和基因-环境相互作用。

方法

在我们的基于人群的病例对照研究中，使用 Taqman 检测方法对 575 例病例和 676 例对照中的 19 个变体进行了基因分型。

结果

受限立方样条模型表明，ADH1B 和 HEL308 均修饰了吸烟包年数与 HNSCC 之间的关联。分类回归树分析表明，吸烟状态、ADH1B、FLJ13089 和 FLJ35784 之间存在高阶相互作用，与 HNSCC 风险有关。与携带 ADH1B T/C+T/T 基因型的终生吸烟者相比，携带 ADH1B C/C 基因型和 FLJ13089 A/G+A/A 基因型的吸烟者患 HNSCC 的风险最高（比值比=1.84）。

结论

我们的研究结果表明，这些变体的风险可能在特定的暴露组中具有特殊的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09f/3662053/e71619adab5a/nihms449440f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09f/3662053/afbe3d6ef564/nihms449440f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09f/3662053/25defe936548/nihms449440f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09f/3662053/9ff87a9bbce3/nihms449440f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09f/3662053/e71619adab5a/nihms449440f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09f/3662053/afbe3d6ef564/nihms449440f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09f/3662053/25defe936548/nihms449440f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09f/3662053/9ff87a9bbce3/nihms449440f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09f/3662053/e71619adab5a/nihms449440f4.jpg

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