Pileri Stefano A, Agostinelli Claudio, Bacci Francesco, Sabattini Elena, Sagramoso Carlo, Falini Brunangelo, Piccaluga Pier Paolo
Hematopathology Section, Department of Hematology and Oncological Sciences "L. and A. Seràgnoli", S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy;
Pediatr Rep. 2011 Jun 22;3 Suppl 2(Suppl 2):e5. doi: 10.4081/pr.2011.s2.e5.
The authors revise the concept of ALK-negative anaplastic large cell lymphoma (ALCL) in the light of the recently updated WHO classification of Tumors of Hematopoietic and Lymphoid Tissues both on biological and clinical grounds. The main histological findings are illustrated as well as the phenotypic, molecular and clinical characteristics. Finally, the biological rationale for possible innovative targeted therapies is presented.
作者根据最近更新的世界卫生组织造血与淋巴组织肿瘤分类，从生物学和临床角度对ALK阴性间变性大细胞淋巴瘤（ALCL）的概念进行了修订。文中阐述了主要的组织学发现以及表型、分子和临床特征。最后，介绍了可能的创新性靶向治疗的生物学原理。
