Hakverdi S, Güngören A, Yaldiz M, Hakverdi A U, Toprak S
Department of Pathology, Faculty of Medicine, Mustafa Kemal University,of Medicine, Mustafa Kemal University, Antakya, Hatay, Turkey.
Eur J Gynaecol Oncol. 2011;32(5):513-5.
The expression of p16 as a tumor suppressor protein was evaluated in a retrospective analysis of paraffin-embedded tissue specimens of leiomyosarcoma (LMS), leiomyoma (LM) and normal myometrium. In this study, we investigated by immunohistochemistry p16 expression in 15 LMSs, 15 LMs and ten normal myometrium. Strong expression of p16 was found in 12 of the 15 LMSs and in three cases weak expression; three LMs had focal and weak p16 staining but none of the normal myometrium. A statistically significant difference regarding the frequency of p16 protein expression was observed between LMS and LM (p: 0.0001). We concluded that the results of this study confirm the overexpression of p16 in LMS. Therefore, the present study suggests that p16 might be a useful immunohistochemical marker which could help in distinguishing uterine LMS from LM and its benign variants.
在一项对平滑肌肉瘤（LMS）、平滑肌瘤（LM）和正常子宫肌层石蜡包埋组织标本的回顾性分析中，评估了肿瘤抑制蛋白p16的表达。在本研究中，我们通过免疫组织化学方法研究了15例LMS、15例LM和10例正常子宫肌层中p16的表达情况。在15例LMS中，12例p16呈强表达，3例呈弱表达；15例LM中有3例p16呈局灶性弱染色，而正常子宫肌层中均无p16表达。LMS和LM之间p16蛋白表达频率存在统计学显著差异（p：0.0001）。我们得出结论，本研究结果证实了LMS中p16的过表达。因此，本研究表明p16可能是一种有用的免疫组织化学标志物，有助于区分子宫LMS与LM及其良性变体。
