Maeda M, Mabuchi S, Matsumoto Y, Hisamatsu T, Ohashi H, Kimura T
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Eur J Gynaecol Oncol. 2011;32(5):542-6.
A 47-year-old woman was diagnosed with extragenital mullerian adenosarcoma with sarcomatous overgrowth. One month after her initial surgery, the patient developed pelvic recurrence, which was completely excised by surgery. However, one month later, the patient developed further recurrences in her pelvis and upper abdomen. A clinical complete response was achieved with three cycles of liposomal doxorubicin and is currently clinically free of disease. So far, including the present case, 23 cases of extragenital mulleian adenosarcoma have been reported in the English literature. Because of the rarity of the reported cases, there are no treatment guidelines based on a good level of evidence. In the current report, through a literature review, we provide information on the activity of pegylated liposomal doxorubicin for extragenital mullerian adenosarcoma with sarcomatous overgrowth.
一名47岁女性被诊断为伴有肉瘤过度生长的生殖器外苗勒管腺肉瘤。初次手术后一个月，患者出现盆腔复发，通过手术将其完全切除。然而，一个月后，患者盆腔和上腹部再次复发。采用三个周期的脂质体阿霉素治疗后获得临床完全缓解，目前临床上无疾病迹象。迄今为止，包括本病例在内，英文文献中已报道23例生殖器外苗勒管腺肉瘤。由于报道的病例罕见，尚无基于充分证据水平的治疗指南。在本报告中，通过文献综述，我们提供了关于聚乙二醇化脂质体阿霉素治疗伴有肉瘤过度生长的生殖器外苗勒管腺肉瘤活性的信息。
