Department of Pathology, University of Florida College of Medicine, Jacksonville, Florida, USA.
Pathologica. 2020 Dec;112(4):219-223. doi: 10.32074/1591-951X-114.
Mullerian adenosarcoma is an uncommon biphasic malignant uterine tumor. It is composed of benign epithelial and malignant stromal elements. We present a case of a 45-year-old woman who presented with post-menopausal bleeding for three months. She had a significant past medical history of pelvic irradiation for squamous carcinoma of cervix 20 years ago. Pathology revealed adenosarcoma with sarcomatous overgrowth. The patient had a recurrence of pure sarcoma three months later and unfortunately succumbed to her disease. The role of radiation in the pathogenesis of adenosarcoma has been uncommonly described compared to its well established role in the development of carcinosarcoma. Our case fulfils the criteria for a radiation induced sarcoma. We review the salient clinical and pathological features of this uncommon lesion highlighting the importance of sarcomatous overgrowth in these lesions and the possible role of radiation in the development of these tumors.
苗勒管腺肉瘤是一种不常见的双相恶性子宫肿瘤。它由良性上皮和恶性间质成分组成。我们报告了一例 45 岁女性，因绝经后出血三个月就诊。她有 20 年前因宫颈鳞癌接受盆腔放疗的重要既往病史。病理显示腺肉瘤伴肉瘤过度生长。患者 3 个月后复发纯肉瘤，不幸死于该病。与放射在癌肉瘤发生中的明确作用相比，放射在腺肉瘤发病机制中的作用罕有描述。我们的病例符合放射诱导肉瘤的标准。我们回顾了这种不常见病变的显著临床和病理特征，强调了这些病变中肉瘤过度生长的重要性以及放射在这些肿瘤发生中的可能作用。
