Hartmann S, Friedrich A, Baum F, Goetze L
Staatlichen Tierärztlichen Untersuchungsamt Stuttgart.
Dtsch Tierarztl Wochenschr. 1990 Jul;97(7):293-6.
The present paper reviews different possibilities of pharmacolegal residues in fish. Sometimes the treatment of fish with registered drugs in therapeutical dosage is provable in spite of keeping the withdrawal time. To that experiences of the persistence and values of Chloramphenicol, Chlortetracycline and Furazolidone proved after therapeutical treatment in fish correlated to the water temperature are compared with results of experiments documented in literature. Investigations on the residues of Enrofloxacin after application of different doses to rainbow trout were carried out. Sometimes the proof of drug residues in fish can be done without an advanced treatment. The recontamination of fish with drugs or their metabolites in environment is discussed as a possibility for drug residues. The carry-over-effect of drug during the animal food production can be also the reason for residues in fish. Experiments with Chloramphenicol contaminated feed in rainbow trout show residues in muscle of fish higher than 10 ppb during the feeding period. Finally the results of residues different drug used in fish--given in literature--are collected in two tables.
本文综述了鱼类中药物残留的不同可能性。有时，尽管遵守了休药期，但仍可证明对鱼类使用了治疗剂量的注册药物。为此，将鱼类治疗后氯霉素、金霉素和呋喃唑酮的残留量及残留值与水温的相关性经验，与文献记载的实验结果进行了比较。对虹鳟鱼施用不同剂量恩诺沙星后的残留情况进行了调查。有时，无需进行先进的处理就能证明鱼类中存在药物残留。讨论了环境中药物或其代谢物对鱼类的再污染是药物残留的一种可能性。动物食品生产过程中药物的残留效应也可能是鱼类中出现残留的原因。用受氯霉素污染的饲料喂养虹鳟鱼的实验表明，在喂养期间，鱼肌肉中的残留量高于10 ppb。最后，文献中给出的鱼类中使用的不同药物的残留结果收集在两个表格中。
