Simopoulos A P
Nephron. 1979;23(2-3):130-5. doi: 10.1159/000181622.
Studies on the growth and development of patients with Bartter's syndrome indicate that severe growth retardation occurs during infancy and early childhood. Delayed adolescent growth spurt has occurred in all patients studied thus far who had manifested the syndrome during infancy. Normal stature is eventually attained. Mental development ranges from normal to brain damage and dysfunction; however, the majority of patients show some degree of mental retardation. The coexistence of Leigh's encephalopathy with Bartter's syndrome in one patient and the finding of severe motor and congnitive retardation with communicating hydrocephalus in another indicate that the prognosis of mental development in some cases of Bartter's syndrome is guarded. Particular attention should be given to maintaining normal nutritional status in all patients, particularly during infancy and early childhood.
对巴特综合征患者生长发育的研究表明，严重生长迟缓发生在婴儿期和幼儿期。在迄今为止所有在婴儿期就已表现出该综合征的患者中，青春期生长突增均出现延迟。最终身高会达到正常。智力发育从正常到脑损伤及功能障碍不等；然而，大多数患者表现出一定程度的智力迟钝。一名患者中 Leigh 脑病与巴特综合征并存，另一名患者中发现严重运动和认知迟缓伴交通性脑积水，这表明某些巴特综合征病例的智力发育预后不容乐观。应特别注意维持所有患者的正常营养状况，尤其是在婴儿期和幼儿期。
