Department of Otolaryngology, NYU School of Medicine, 522 First Ave., New York, NY 10016, USA.
Curr Opin Neurobiol. 2012 Feb;22(1):34-44. doi: 10.1016/j.conb.2011.10.013. Epub 2011 Nov 3.
Electrophysiological recordings from behaving animals provide an unparalleled view into the functional role of individual neurons. Intracellular approaches can be especially revealing as they provide information about a neuron's inputs and intrinsic cellular properties, which together determine its spiking output. Recent technical developments have made intracellular recording possible during an ever-increasing range of behaviors in both head-fixed and freely moving animals. These recordings have yielded fundamental insights into the cellular and circuit mechanisms underlying neural activity during natural behaviors in such areas as sensory perception, motor sequence generation, and spatial navigation, forging a direct link between cellular and systems neuroscience.
在行为动物中进行电生理记录为研究单个神经元的功能作用提供了无与伦比的视角。细胞内方法尤其具有启发性，因为它们提供了有关神经元输入和内在细胞特性的信息，这些信息共同决定了其尖峰输出。最近的技术发展使得在头固定和自由移动的动物进行越来越多的行为中进行细胞内记录成为可能。这些记录为神经活动的细胞和电路机制提供了重要的见解，这些机制在感觉感知、运动序列生成和空间导航等领域的自然行为中发挥作用，在细胞和系统神经科学之间建立了直接联系。
