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正电子发射断层扫描在肺癌评估中的使用和误用。

The use and misuse of positron emission tomography in lung cancer evaluation.

机构信息

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Keck School of Medicine of USC, 2020 Zonal Avenue, IRD Room 723, Los Angeles, CA 90033, USA.

出版信息

Clin Chest Med. 2011 Dec;32(4):749-62. doi: 10.1016/j.ccm.2011.08.012.

DOI:10.1016/j.ccm.2011.08.012
PMID:22054883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3210441/
Abstract

This article discusses the potential benefits and limitations of positron emission tomography (PET) for characterizing lung nodules, staging the mediastinum, identifying occult distant metastasis, determining prognosis and treatment response, guiding plans for radiation therapy, restaging during and after treatment, and selecting targets for tissue sampling. The key findings from the medical literature are presented regarding the capabilities and fallibilities of PET in lung cancer evaluation, including characterization of pulmonary nodules and staging in patients with known or suspected non-small-cell lung cancer. The discussion is limited to PET imaging with fluorodeoxyglucose.

摘要

本文讨论了正电子发射断层扫描(PET)在肺结节特征描述、纵隔分期、隐匿性远处转移的识别、预后和治疗反应判断、放射治疗计划指导、治疗期间和治疗后的再分期以及组织取样靶点选择方面的潜在优势和局限性。重点介绍了关于氟脱氧葡萄糖 PET 在肺癌评估中的作用和局限性的医学文献中的关键发现,包括对已知或疑似非小细胞肺癌患者肺结节的特征描述和分期。讨论仅限于氟脱氧葡萄糖 PET 成像。

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本文引用的文献

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Combined use of positron emission tomography and volume doubling time in lung cancer screening with low-dose CT scanning.低剂量 CT 扫描肺癌筛查中使用正电子发射断层扫描和体积倍增时间的联合应用。
Thorax. 2011 Apr;66(4):315-9. doi: 10.1136/thx.2010.136747. Epub 2010 Dec 17.
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Monitoring response to antiangiogenic therapy in non-small cell lung cancer using imaging markers derived from PET and dynamic contrast-enhanced MRI.使用来自 PET 和动态对比增强 MRI 的成像标志物监测非小细胞肺癌对血管生成抑制剂治疗的反应。
J Nucl Med. 2011 Jan;52(1):48-55. doi: 10.2967/jnumed.110.078261. Epub 2010 Dec 13.
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Survival of patients with clinical stage IIIA non-small cell lung cancer after induction therapy: age, mediastinal downstaging, and extent of pulmonary resection as independent predictors.诱导治疗后临床 IIIA 期非小细胞肺癌患者的生存:年龄、纵隔降期和肺切除范围是独立预测因素。
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PET scans in radiotherapy planning of lung cancer.肺癌放射治疗计划中的 PET 扫描。
Radiother Oncol. 2010 Sep;96(3):335-8. doi: 10.1016/j.radonc.2010.07.002. Epub 2010 Jul 23.
5
Cumulative incidence of false-positive test results in lung cancer screening: a randomized trial.肺癌筛查中假阳性测试结果的累积发生率:一项随机试验。
Ann Intern Med. 2010 Apr 20;152(8):505-12, W176-80. doi: 10.7326/0003-4819-152-8-201004200-00007.
6
Primary tumor standardized uptake value measured on fluorodeoxyglucose positron emission tomography is of prognostic value for survival in non-small cell lung cancer: update of a systematic review and meta-analysis by the European Lung Cancer Working Party for the International Association for the Study of Lung Cancer Staging Project.氟脱氧葡萄糖正电子发射断层扫描测量的原发肿瘤标准化摄取值对非小细胞肺癌生存具有预后价值:欧洲肺癌工作组为国际肺癌研究协会分期项目进行的系统评价和荟萃分析更新。
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J Thorac Oncol. 2009 Dec;4(12):1473-9. doi: 10.1097/JTO.0b013e3181bccbc6.