Heybach J P, Vernikos-Danellis J
Neuroendocrinology. 1979;28(5):329-38. doi: 10.1159/000122880.
Rats that were maintained on a 23-h food and water deprivation schedule (food and water available between 09:00 and 10:00 h) for 21 days, and whose blood was sampled at various times following initiation of ingestion showed a decrease in plasma adrenocorticotrophin (ACTH) concurrent with dropping plasma levels of corticosterone (COR). This drop occurred from elevated levels of these hormones, most likely due to altered circadian patterns of pituitary-adrenal activity as a result of the rhythm-entraining properties of the feeding schedule. This inhibition of secretion of ACTH is interpreted as reflecting the inhibitory effect of a central nervous system mechanism that can affect ACTH secretion independently of corticosteroid negative feedback.
将大鼠置于23小时禁食禁水的时间表（09:00至10:00之间可获取食物和水）下持续21天，在开始摄入食物后的不同时间采集血液样本，结果显示血浆促肾上腺皮质激素（ACTH）水平下降，同时血浆皮质酮（COR）水平也随之降低。这些激素水平从升高状态下降，很可能是由于进食时间表的节律调节特性改变了垂体-肾上腺活动的昼夜节律模式。ACTH分泌的这种抑制被解释为反映了一种中枢神经系统机制的抑制作用，该机制可独立于皮质类固醇负反馈影响ACTH的分泌。
