亚太队列研究协作组中的糖尿病、体重指数与冠心病、缺血性和出血性卒中等发病风险。
Diabetes, body mass index and the excess risk of coronary heart disease, ischemic and hemorrhagic stroke in the Asia Pacific Cohort Studies Collaboration.
机构信息
The George Institute for Global Health, University of Sydney, Sydney, Australia.
出版信息
Prev Med. 2012 Jan;54(1):38-41. doi: 10.1016/j.ypmed.2011.10.010. Epub 2011 Oct 28.
OBJECTIVE
To examine the effects of diabetes on coronary heart disease, ischemic and hemorrhagic stroke and cardiovascular disease according to category of body mass index.
METHODS
Data on 161,161 men and women from 31 cohorts (baseline years, 1966-99; mean follow-up, 2-24 years) from the Asia Pacific Cohort Studies Collaboration were analyzed using Cox regression, stratified by sex and study and adjusted for age, systolic blood pressure and smoking. Diabetes was self-reported in all but one study. Body mass index was divided into five categories according to the World Health Organization Asian criteria.
RESULTS
The hazard ratio (diabetes v. not) for cardiovascular disease was 1.83 (95% confidence interval, 1.66-2.01). Across body mass index categories, this hazard ratio did not change significantly (p=0.19). Similar lack of difference across body mass index groups was found for coronary heart disease (p=0.33), ischemic stroke (p=0.97) and hemorrhagic stroke (p=0.98).
CONCLUSIONS
Body mass index does not modify the effect of diabetes on major cardiovascular outcomes.
目的
根据体重指数类别，研究糖尿病对冠心病、缺血性卒中和出血性卒中和心血管疾病的影响。
方法
亚太队列研究协作组对来自 31 项队列研究（基线年份为 1966-99 年；平均随访时间为 2-24 年）的 161161 名男性和女性的数据进行了 Cox 回归分析，按照性别和研究进行分层，并调整了年龄、收缩压和吸烟因素。除了一项研究外，所有研究均采用自我报告的方法来诊断糖尿病。体重指数根据世界卫生组织亚洲标准分为五个类别。
结果
心血管疾病的风险比（糖尿病与非糖尿病）为 1.83（95%置信区间，1.66-2.01）。在体重指数类别中，这一风险比没有显著变化（p=0.19）。在冠心病（p=0.33）、缺血性卒中和出血性卒中（p=0.97 和 p=0.98）方面，也未发现体重指数组之间存在显著差异。
结论
体重指数不能改变糖尿病对主要心血管结局的影响。
Zotero 插件