Locatelli F, Giovanelli E, Neretto G, Furno F, Pellerito R
Minerva Med. 1979 Mar 17;70(13):925-33.
56 cases of myeloma observed since 1956 are reviewed and it is noted that course, prognosis and survival have changed in relation to the improvement in diagnostic procedures and therapeutic aids. The recent introduction of polychemotherapeutic approaches based on theoretical considerations has not yet been fully vetted in the clinic although a higher percentage of remissions compared to that obtained by monochemotherapy would seem to be confirmed. Personal experience with a new polychemotherapeutic schema in advanced myeloma resistant to monochemotherapy + prednisone is reported.
回顾了自1956年以来观察到的56例骨髓瘤病例，注意到随着诊断程序和治疗手段的改进，病程、预后和生存率都发生了变化。基于理论考虑最近引入的多药化疗方法在临床上尚未得到充分验证，尽管与单药化疗相比，似乎有更高比例的缓解得到证实。报告了在对单药化疗+泼尼松耐药的晚期骨髓瘤中使用一种新的多药化疗方案的个人经验。
