Shinohara M, Matsuura Y, Baba S, Kashimura M
Department of Obstetrics and Gynecology, University of Occupational and Environmental Health, School of Medicine, Fukuoka.
Nihon Sanka Fujinka Gakkai Zasshi. 1990 Jun;42(6):561-6.
Seventeen multiple primary cancers including 16 double cancers and one triple cancer were found in 316 patients with gynecologic malignancies who were treated in our department from 1984 to 1988. All pathologic slides but one were reviewed, and cases with possible metastasis or recurrence were not included in this study. The incidence of multiple primary cancers in gynecologic malignancies was 5.4%. Multiple primary cancers were encountered in 4.4% of 205 cervical cancers (including carcinoma in situ), 15.2% of 33 endometrial cancers, and 8.6% of 58 ovarian cancers (including low potential malignancy), respectively. The most frequent sites of other cancers were seen in the large intestine and rectum (5/17), breast (4/17), and gynecologic organs (3/17). Higher incidences were seen in our study that in those in domestic literature. This is probably because detailed anamnesis and gastrointestinal series were obtained in most gynecologic malignancies (especially in endometrial or ovarian cancer).
1984年至1988年期间，在我院接受治疗的316例妇科恶性肿瘤患者中，发现了17例多原发性癌症，其中包括16例双癌和1例三癌。除1例病理切片外，其余所有切片均经过复查，本研究未纳入可能存在转移或复发的病例。妇科恶性肿瘤中多原发性癌症的发生率为5.4%。在205例宫颈癌（包括原位癌）中，多原发性癌症的发生率为4.4%；在33例子宫内膜癌中为15.2%；在58例卵巢癌（包括低度潜在恶性肿瘤）中为8.6%。其他癌症最常见的部位是大肠和直肠（5/17）、乳腺（4/17）和妇科器官（3/17）。与国内文献报道相比，本研究中的发生率更高。这可能是因为大多数妇科恶性肿瘤（尤其是子宫内膜癌或卵巢癌）患者都进行了详细的既往史询问和胃肠道造影检查。
