Wen Jian Guo, Chang Qing Long, Lou An Feng, Li Zhen Zhen, Lu Shan, Wang Yan, Wang Ya Lun, Hu Jin Hua, Mao Shu Ping, Zhang Yan, Xue Rui, Ren Chuanchuan, Xing Lu, Zhang Guo Xian, Zhang Shengjun, Djurhuus Jens Christian, Frøkiaer Jørgen
Urodynamic Center, Department of Urology of the First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medicine of Zhengzhou University, Zhengzhou, China. jgwen @ zzu.edu.cn
Urol Int. 2011;87(4):429-33. doi: 10.1159/000330795. Epub 2011 Nov 1.
To summarize the clinical features and follow-up, the effects of melamine-tainted milk powder (MMP) consumption on kidney and body growth in children who suffered from melamine-related urinary stones (MUS) 2 years earlier were checked.
Body height and weight, kidney and bladder morphology monitored by ultrasound, urinalysis and renal function were recorded. Plain abdominal radiography was performed for differential diagnosis. The first follow-up was carried out at 15 months and the second 2 years later for patients who showed any abnormality at the first follow-up. Two hundred age- and gender-matched cohorts were included.
All cases received conservative treatment in hospital. Fifteen months of follow-up was successfully carried out in 167 cases. 91 children had residual MUS at the time of discharge, 58 MUS disappeared completely, 25 dissolved partially, 1 increased in size, and 7 did not change. At 2 years of follow-up, the residual stones all disappeared except for 1 case; the patient who showed a delayed development with regard to height caught up at 24 months of follow-up.
Conservative treatment shows a high effectiveness in cases with residual MUS. Consumption of MMP with timely treatment did not demonstrate an evident impact on kidney and bladder although body height is slightly affected in a few cases.
总结临床特征及随访情况，对2年前患三聚氰胺相关泌尿系统结石（MUS）的儿童，检查食用三聚氰胺污染奶粉（MMP）对其肾脏及身体生长的影响。
记录身高、体重，通过超声监测肾脏和膀胱形态、尿常规及肾功能。进行腹部平片检查以鉴别诊断。首次随访在15个月时进行，对首次随访有异常的患者，2年后进行第二次随访。纳入200名年龄和性别匹配的队列。
所有病例均在医院接受保守治疗。167例成功进行了15个月的随访。出院时91例儿童有残余MUS，58例MUS完全消失，25例部分溶解，1例增大，7例无变化。在2年随访时，除1例患者外，残余结石均消失；身高发育迟缓的患者在随访24个月时追赶上来。
保守治疗对残余MUS病例显示出高有效性。及时治疗的情况下，食用MMP对肾脏和膀胱未显示明显影响，尽管少数病例身高略有影响。
