Department of Neurology, Ospedale San Martino Belluno, Viale Europa 22, 32100, Belluno, Italy.
Neurol Sci. 2012 Jun;33(3):669-72. doi: 10.1007/s10072-011-0834-7. Epub 2011 Nov 6.
Tick borne encephalitis virus infection usually shows a biphasic course. In the first stage of illness symptoms are similar to a flu-like syndrome, then after a defervescence period, fever may represent with neurological manifestations ranging from mild meningitis to severe encephalomyelitis. We report the clinical case of an adult man presented with an acute proximal hyposthenia, severe hyperckemia, clinical and laboratoristic evidence of acute tick borne virus infection. This virus has a favourite tropism for the anterior horn cells of the cervical spine segment. Polio-like syndrome, usually affecting the upper limbs, is the clinical phenotype of an infection of the cervical motoneurons. Usually myelitis is associated to severe encephalitis and a complete diagnosis may be difficult in comatose patients. Rarely, an isolated polio-like syndrome may be the sole neurological complication of tick-borne encephalitis.
蜱传脑炎病毒感染通常呈双相病程。在疾病的第一阶段,症状类似于流感样综合征,然后在退热期后,发热可能表现为从轻度脑膜炎到严重脑脊髓炎的神经表现。我们报告了一例成年男性的临床病例,表现为急性近端无力、严重高肌酸激酶血症、急性蜱传病毒感染的临床和实验室证据。该病毒对颈椎段前角细胞有特别的嗜性。类脊灰综合征,通常影响上肢,是颈运动神经元感染的临床表型。通常,脊髓炎与严重脑炎相关,对于昏迷患者,完整的诊断可能很困难。罕见情况下,孤立的类脊灰综合征可能是蜱传脑炎的唯一神经并发症。