Dublin Diabetes Pregnancy Centre, Mater Misericordiae University Hospital, 30 Eccles Street, Dublin 7, Ireland.
Ir J Med Sci. 2012 Mar;181(1):105-9. doi: 10.1007/s11845-011-0781-6. Epub 2011 Nov 5.
To compare the pregnancy outcomes in all T1DMP attending at combined (diabetes-obstetric) outpatients clinics in three university teaching hospitals in Dublin from 1995 to 2006 with a non-diabetic control population (C) attending at antenatal outpatient clinics at the same hospitals over the same period.
T1DMP (n = 600) were compared with control non-diabetic pregnancies (n = 142,498).
The spontaneous abortion rate was 15% in T1DMP versus 8% in C (p < 0.0001). Perinatal mortality rate was 3.3% in T1DMP compared to 0.9% in C (p < 0.001). The incidence of foetal macrosomia was 29% in T1DMP versus 16% in C (p < 0.001).
Pregnancy outcomes in T1DMP remain worse than in the general population despite management of T1DMP in combined obstetric/diabetes clinics in a single centre using similar management protocols. These outcomes in our study population of T1DMP in Dublin appear better than some previously reported studies.
比较 1995 年至 2006 年都柏林三所大学教学医院的联合（糖尿病-产科）门诊就诊的所有 1 型糖尿病合并妊娠患者（T1DMP）与同期在同一医院产前门诊就诊的非糖尿病对照人群（C）的妊娠结局。
将 T1DMP（n=600）与非糖尿病对照妊娠（n=142498）进行比较。
T1DMP 的自然流产率为 15%，C 为 8%（p<0.0001）。T1DMP 的围产儿死亡率为 3.3%，C 为 0.9%（p<0.001）。T1DMP 的巨大儿发生率为 29%，C 为 16%（p<0.001）。
尽管在单一中心的联合产科/糖尿病诊所中使用类似的管理方案管理 T1DMP，但 T1DMP 的妊娠结局仍比一般人群差。与一些先前报道的研究相比，我们在都柏林的 T1DMP 研究人群中的这些结局似乎更好。
