• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

N-（4-氯苯基）-4-（嘧啶-2-基）哌嗪-1-甲酰胺

N-(4-Chloro-phen-yl)-4-(pyrimidin-2-yl)piperazine-1-carboxamide.

作者信息

Li Yu-Feng

机构信息

Microscale Science Institute, Department of Chemistry and Chemical Engineering, Weifang University, Weifang 261061, People's Republic of China.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2011 Oct 1;67(Pt 10):o2575. doi: 10.1107/S160053681103515X. Epub 2011 Sep 14.

DOI:10.1107/S160053681103515X
PMID:22058741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3201268/
Abstract

The title compound, C(15)H(16)ClN(5)O, contains two mol-ecules, A and B, in the asymmetric unit, in which the dihedral angles between the terminal aromatic rings are 42.41 (17) and 45.77 (18)°. The central six-membered ring in both mol-ecules has a chair conformation with equatorial substituents. In the crystal, mol-ecules are linked into [100] C(4) chains of alternating A and B mol-ecules by N-H⋯O hydrogen bonds.

摘要

标题化合物C(15)H(16)ClN(5)O的不对称单元中包含两个分子A和B，其中末端芳环之间的二面角分别为42.41 (17)°和45.77 (18)°。两个分子中的中央六元环均呈椅式构象，取代基位于赤道平面。在晶体中，分子通过N-H⋯O氢键连接成由A和B分子交替排列的[100] C(4)链。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/497e/3201268/37ed0be4698b/e-67-o2575-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/497e/3201268/37ed0be4698b/e-67-o2575-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/497e/3201268/37ed0be4698b/e-67-o2575-fig1.jpg

相似文献

1
N-(4-Chloro-phen-yl)-4-(pyrimidin-2-yl)piperazine-1-carboxamide.N-（4-氯苯基）-4-（嘧啶-2-基）哌嗪-1-甲酰胺
Acta Crystallogr Sect E Struct Rep Online. 2011 Oct 1;67(Pt 10):o2575. doi: 10.1107/S160053681103515X. Epub 2011 Sep 14.
2
4-{[5-(4-Chloro-phen-yl)-1-(4-fluoro-phen-yl)-1H-pyrazol-3-yl]carbon-yl}-N-ethyl-piperazine-1-carboxamide.4-{[5-(4-氯苯基)-1-(4-氟苯基)-1H-吡唑-3-基]羰基}-N-乙基哌嗪-1-甲酰胺
Acta Crystallogr Sect E Struct Rep Online. 2011 Jul 1;67(Pt 7):o1747-8. doi: 10.1107/S1600536811023178. Epub 2011 Jun 18.
3
4-{[5-(4-Chloro-phen-yl)-1-(4-fluoro-phen-yl)-1H-pyrazol-3-yl]carbon-yl}-N-(4-cyano-phen-yl)piperazine-1-carboxamide.4-{[5-(4-氯苯基)-1-(4-氟苯基)-1H-吡唑-3-基]羰基}-N-(4-氰基苯基)哌嗪-1-甲酰胺
Acta Crystallogr Sect E Struct Rep Online. 2010 Sep 15;66(Pt 10):o2563-4. doi: 10.1107/S1600536810036159.
4
4-(4-Chloro-phen-yl)-6-hydr-oxy-5-(2-thienyl-carbonyl)-6-(trifluoro-meth-yl)-3,4,5,6-tetra-hydro-pyrimidin-2(1H)-one monohydrate.4-（4-氯苯基）-6-羟基-5-（2-噻吩羰基）-6-（三氟甲基）-3,4,5,6-四氢嘧啶-2（1H）-酮一水合物
Acta Crystallogr Sect E Struct Rep Online. 2009 May 20;65(Pt 6):o1339. doi: 10.1107/S1600536809017097.
5
Ethyl 2-{N-[N-(4-chloro-6-methoxy-pyrimidin-2-yl)carbamo-yl]sulfamo-yl}benzoate.2-{N-[N-(4-氯-6-甲氧基嘧啶-2-基)氨基甲酰基]氨磺酰基}苯甲酸乙酯
Acta Crystallogr Sect E Struct Rep Online. 2008 Jun 13;64(Pt 7):o1248. doi: 10.1107/S1600536808017029.
6
N-(2-{[5-Bromo-2-(piperidin-1-yl)pyrimidin-4-yl]sulfan-yl}-4-meth-oxy-phen-yl)benzene-sulfonamide.N-（2-{[5-溴-2-（哌啶-1-基）嘧啶-4-基]硫基}-4-甲氧基苯基）苯磺酰胺
Acta Crystallogr Sect E Struct Rep Online. 2012 Nov 1;68(Pt 11):o3209-10. doi: 10.1107/S1600536812043668. Epub 2012 Oct 27.
7
N-(4-Chloro-phen-yl)-4-methyl-piperazine-1-carboxamide.N-（4-氯苯基）-4-甲基哌嗪-1-甲酰胺
Acta Crystallogr Sect E Struct Rep Online. 2011 Sep 1;67(Pt 9):o2453. doi: 10.1107/S1600536811034283. Epub 2011 Aug 27.
8
1-[4-(4-Chloro-phen-yl)piperazin-1-yl]-3-(6-oxo-3,4-diphenyl-1,6-dihydro-pyridazin-1-yl)propan-1-one.1-[4-(4-氯苯基)哌嗪-1-基]-3-(6-氧代-3,4-二苯基-1,6-二氢哒嗪-1-基)丙-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2012 Sep 1;68(Pt 9):o2720. doi: 10.1107/S160053681203543X. Epub 2012 Aug 15.
9
N-(2-Chloro-phen-yl)-4-hydr-oxy-2H-1,2-benzothia-zine-3-carboxamide 1,1-dioxide.
Acta Crystallogr Sect E Struct Rep Online. 2009 Aug 29;65(Pt 9):o2279-80. doi: 10.1107/S1600536809033972.
10
N-(4-Chloro-phen-yl)-4-ethyl-piperazine-1-carboxamide.N-（4-氯苯基）-4-乙基哌嗪-1-甲酰胺
Acta Crystallogr Sect E Struct Rep Online. 2011 Oct 1;67(Pt 10):o2574. doi: 10.1107/S1600536811035331. Epub 2011 Sep 14.

引用本文的文献

1
Three closely related 1-[(1,3-benzodioxol-5-yl)methyl]-4-(halobenzo-yl)piperazines: similar mol-ecular structures but different inter-molecular inter-actions.三种紧密相关的1-[(1,3-苯并二氧杂环戊烯-5-基)甲基]-4-(卤代苯甲酰基)哌嗪：相似的分子结构但不同的分子间相互作用。
Acta Crystallogr E Crystallogr Commun. 2019 Jan 11;75(Pt 2):202-207. doi: 10.1107/S2056989019000458. eCollection 2019 Feb 1.
2
The crystal structure of 1-(2-iodo-benzo-yl)-4-(pyrimidin-2-yl)piperazine: a three-dimensional hydrogen-bonded framework, augmented by π-π stacking inter-actions and I⋯N halogen bonds.1-(2-碘苯甲酰基)-4-(嘧啶-2-基)哌嗪的晶体结构：一个三维氢键框架，通过π-π堆积相互作用和I⋯N卤键得到增强。
Acta Crystallogr E Crystallogr Commun. 2019 Jan 4;75(Pt 2):129-133. doi: 10.1107/S205698901801811X. eCollection 2019 Feb 1.
3

本文引用的文献

1
N-(4-Chloro-phen-yl)-4-methyl-piperidine-1-carboxamide.N-（4-氯苯基）-4-甲基哌啶-1-甲酰胺
Acta Crystallogr Sect E Struct Rep Online. 2011 Jul 1;67(Pt 7):o1796. doi: 10.1107/S1600536811024123. Epub 2011 Jun 25.
2
N-(4-Chloro-phen-yl)pyrrolidine-1-carboxamide.N-（4-氯苯基）吡咯烷-1-甲酰胺
Acta Crystallogr Sect E Struct Rep Online. 2011 Jul 1;67(Pt 7):o1792. doi: 10.1107/S1600536811024111. Epub 2011 Jun 25.
3
A short history of SHELX.SHELX简史。
Crystal structures of 4-(pyrimidin-2-yl)piperazin-1-ium chloride and 4-(pyrimidin-2-yl)piperazin-1-ium nitrate.4-（嘧啶-2-基）哌嗪-1-鎓氯化物和4-（嘧啶-2-基）哌嗪-1-鎓硝酸盐的晶体结构
Acta Crystallogr Sect E Struct Rep Online. 2014 Sep 13;70(Pt 10):203-6. doi: 10.1107/S1600536814020169. eCollection 2014 Oct 1.
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.