Messing Rita B, Lytle Loy D
University of California at Irvine, Department of Psychobiology, Irvine, Calif, 92717 and Massachusetts Institute of Technology, Department of Nutrition and Food Science, Cambridge, Mass. 02139 U.S.A.
Pain. 1977 Oct;4(1):1-21. doi: 10.1016/0304-3959(77)90083-5.
Experimental evidence is reviewed showing that brain and spinal cord serotonergic neurons are involved in nociceptive responses, as well as in the analgesic effects of opiate narcotics. This evidence, based on studies employing pharmacological, surgical, electrophysiological, and dietary manipulations of central nervous system serotonergic neurotransmission, suggests that increases in the activity of brain and spinal cord serotonin neurons are associated with analgesia and enhanced antinociceptive drug potency, whereas decreases in the activities of these neurons correlate with hyperalgesia and diminished analgesic drug potency.
综述的实验证据表明，脑和脊髓中的5-羟色胺能神经元参与伤害性反应以及阿片类麻醉药的镇痛作用。基于对中枢神经系统5-羟色胺能神经传递进行药理学、手术、电生理学和饮食干预的研究，该证据表明，脑和脊髓5-羟色胺神经元活性增加与镇痛及增强的抗伤害感受药物效力相关，而这些神经元活性降低则与痛觉过敏及镇痛药物效力减弱相关。
