School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Physiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Arch Iran Med. 2024 Aug 1;27(8):456-464. doi: 10.34172/aim.28772.
Peripheral neuropathic pain is a result of damage/illness of the peripheral nerves. The mechanisms caused by its pathophysiology are not completely understood.
Imipramine is a tricyclic antidepressant that is sometimes used to treat neuropathic pain. Moreover, citicoline is considered a novel adjuvant for painful disorders such as neuropathic pain. So, a possible interaction between imipramine and citicoline on pain behavior was examined in nerve-ligated mice using tail-flick and hot plate tests.
The results indicated that induction of neuropathic pain by sciatic nerve ligation caused hyperalgesia in nerve-ligated mice. On the other hand, intraperitoneal (i.p.) administration of citicoline (50, 75, and 100 mg/kg), and imipramine (2.5 and 5 mg/kg) induced anti-hyperalgesic and anti-nociceptive effects in nerve-ligated mice. Furthermore, citicoline potentiated the anti-hyperalgesic and anti-nociceptive effects of imipramine when they were co-administrated in nerve-ligated mice. Interestingly, there was an additive effect between imipramine and citicoline upon induction of anti-hyperalgesic and anti-nociceptive effects in nerve-ligated mice.
Therefore, it can be concluded that citicoline (as an adjuvant substance) enhanced the efficacy of imipramine for the modulation of pain behavior in nerve-ligated mice.
周围神经性疼痛是外周神经损伤/疾病的结果。其病理生理学引起的机制尚未完全了解。
丙咪嗪是一种三环类抗抑郁药，有时用于治疗神经性疼痛。此外，胞磷胆碱被认为是一种治疗神经性疼痛等疼痛障碍的新型辅助药物。因此，在结扎坐骨神经的小鼠中，使用尾巴闪烁和热板试验检查丙咪嗪和胞磷胆碱之间可能的相互作用对疼痛行为的影响。
结果表明，坐骨神经结扎引起的神经性疼痛诱导导致结扎小鼠出现痛觉过敏。另一方面，腹腔内（i.p.）给予胞磷胆碱（50、75 和 100 mg/kg）和丙咪嗪（2.5 和 5 mg/kg）可在结扎小鼠中诱导抗痛觉过敏和抗伤害感受作用。此外，当在结扎小鼠中共同给予时，胞磷胆碱增强了丙咪嗪的抗痛觉过敏和抗伤害感受作用。有趣的是，在诱导结扎小鼠的抗痛觉过敏和抗伤害感受作用时，丙咪嗪和胞磷胆碱之间存在相加作用。
因此，可以得出结论，胞磷胆碱（作为辅助物质）增强了丙咪嗪对结扎小鼠疼痛行为调节的疗效。
