Department of Cranio-Maxillofacial Surgery, University Hospital, Freiburgsstrasse 10, Bern, Switzerland.
J Periodontol. 2012 Jun;83(6):757-65. doi: 10.1902/jop.2011.110418. Epub 2011 Nov 7.
Distraction of the periosteum results in the formation of new bone in the gap between the periosteum and the original bone. We postulate that the use of a barrier membrane would be beneficial for new bone formation in periosteal distraction.
To selectively influence the contribution of the periosteum, a distraction plate with perforations was used alone or covered by a collagen barrier membrane. All animals were subjected to a 7-day latency period and a 10-day distraction period with a rate of 0.1 mm/day. Four animals per group with or without a barrier membrane were sacrificed at 2, 4, and 6 weeks after the end of the distraction. The height of new bone generated relative to the areas bound by the parent bone and the periosteum was determined by histomorphometric methods.
New bone was found in all groups. At the periphery of the distraction plate, significant differences in bone height were found between the hinge and the distraction screw for the group without barrier membrane at 2 weeks (0.39 ± 0.19 mm) compared to 4 weeks (0.84 ± 0.44 mm; P = 0.002) and 6 weeks (1.06 ± 0.39 mm; P = 0.004). Differences in maximum bone height with and without a barrier membrane were observed laterally to the distraction plate at 2 weeks (1.22 ± 0.64 versus 0.55 ± 0.14 mm; P = 0.019) and 6 weeks (1.61 ± 0.56 versus 0.73 ± 0.33 mm; P = 0.003) of the consolidation period.
Within the limitations of the present study, the application of a barrier membrane may be considered beneficial for new bone formation induced by periosteal distraction.
骨膜的牵张会导致骨膜和原始骨之间的间隙中新骨的形成。我们推测，使用屏障膜将有利于骨膜牵张中新骨的形成。
为了有选择地影响骨膜的贡献，使用带有穿孔的牵张板单独使用或覆盖胶原屏障膜。所有动物均经过 7 天潜伏期和 10 天牵张期，牵张速度为 0.1mm/天。每组 4 只动物，有无屏障膜，在牵张结束后 2、4 和 6 周时处死。通过组织形态计量学方法确定相对于原始骨和骨膜边界生成的新骨高度。
所有组均发现新骨。在无屏障膜组，2 周时，铰链与牵张螺钉之间的骨高度差异显著（0.39 ± 0.19mm），而 4 周（0.84 ± 0.44mm；P = 0.002）和 6 周（1.06 ± 0.39mm；P = 0.004）。在牵张板外侧，有和无屏障膜组的最大骨高度差异在 2 周（1.22 ± 0.64 与 0.55 ± 0.14mm；P = 0.019）和 6 周（1.61 ± 0.56 与 0.73 ± 0.33mm；P = 0.003）时观察到。
在本研究的限制范围内，屏障膜的应用可能被认为有利于骨膜牵张诱导的新骨形成。
