Department of Organic Chemistry, Higher Teachers Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon.
Fitoterapia. 2012 Jan;83(1):204-8. doi: 10.1016/j.fitote.2011.10.014. Epub 2011 Oct 28.
Phytochemical investigation of the stem bark of Stereospermum acuminatissimum K. Schum. resulted in the isolation of 21 compounds, including two new guanine derivatives, 1,3,7-trimethylguanin-1/3-ium (1) and 3,7-dimethylguanin-1/3-ium (2), and one new phenolic long chain ester, 2-(4-hydroxyphenyl)ethyl hentriacontanoate (3). The known compounds were identified as sterequinones A, F, and H (4, 5, and 6), zenkequinones A-B (7-8), p-coumaric acid (9), methyl caffeate (10), caffeic acid (11), psilalic acid (12), syringaldehyde (13), norviburtinal (14), specioside (15), verminoside (16), tyrosol (17), eutigoside A (18), ellagic acid (19), atranorin (20), and ursolic acid (21). The metabolites were screened for their potential against urease and α-chymotrypsin enzymes, as urease is targeted in peptic ulcer while α-chymotrypsin is used to remove protein debris in ulcer. Compound 20 was found to be excellent urease inhibitor with IC(50) value of 18.2 ± 0.03 μM. Compounds 13 and 18-20 are reported for the first time from the genus Stereospermum. The chemotaxonomic significance of the isolated compounds was also described.
从 Stereospermum acuminatissimum K. Schum. 的茎皮中进行植物化学研究，分离得到了 21 种化合物，包括两种新的鸟嘌呤衍生物，1,3,7-三甲基鸟嘌呤-1/3-鎓（1）和 3,7-二甲基鸟嘌呤-1/3-鎓（2），以及一种新的酚类长链酯，2-(4-羟基苯基)乙基 hentriacontanoate（3）。已知化合物分别鉴定为 sterequinones A、F 和 H（4、5 和 6）、zenkequinones A-B（7-8）、对羟基苯甲酸（9）、甲基咖啡酸（10）、咖啡酸（11）、 psilalic 酸（12）、丁香醛（13）、norviburtinal（14）、specioside（15）、verminoside（16）、tyrosol（17）、eutigoside A（18）、鞣花酸（19）、atranorin（20）和熊果酸（21）。这些代谢物被筛选出对尿素酶和 α-糜蛋白酶的潜在抑制作用，因为尿素酶是治疗消化性溃疡的靶点，而 α-糜蛋白酶用于清除溃疡中的蛋白质碎片。化合物 20 被发现是一种优秀的尿素酶抑制剂，IC50 值为 18.2±0.03μM。化合物 13 和 18-20 是首次从 Stereospermum 属中分离得到的。还描述了分离化合物的化学生态学意义。
