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尖叶羽叶楸茎皮中的酚酯类及其他成分。

Phenol esters and other constituents from the stem barks of Stereospermum acuminatissimum.

作者信息

Sob Sylvain Valère Tanemossu, Wabo Hippolyte Kamdem, Tang Chun-Ping, Tane Pierre, Ngadjui Bonaventure Tchaleu, Ye Yang

机构信息

Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.

出版信息

J Asian Nat Prod Res. 2011 Dec;13(12):1128-34. doi: 10.1080/10286020.2011.619182. Epub 2011 Oct 19.

Abstract

A new ester, 2-(4'-hydroxyphenyl)ethyl dotriacontanoate (1), and a new inseparable mixture of octacosan-1,28-dioldiferulate and triacontan-1,30-dioldiferulate (2) were isolated from the stem barks of Stereospermum acuminatissimum, along with 24 known compounds including 4 triterpenoids, 11 anthraquinones, 2 lignans, 3 phenylpropanoids, 2 4-hydroxyphenethyl esters, 1 methoxyphenol, and 1 iridoid. The structures of the new metabolites were determined with the help of spectroscopic data including extensive 2D NMR spectroscopy. The known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. The compounds were tested against Candida albicans ATCC 24433, C. albicans ATCC 90028, Candida glabrata ATCC 90030, Candida krusei ATCC 6258, and Candida parapsilosis ATCC 22019. Some of them were moderately active.

摘要

从尖叶羽叶楸的茎皮中分离出一种新的酯类化合物2-(4'-羟基苯基)乙基三十二烷酸酯(1),以及一种新的二十八烷-1,28 -二醇二阿魏酸酯和三十烷-1,30 -二醇二阿魏酸酯的不可分离混合物(2),同时还分离出24种已知化合物,包括4种三萜类化合物、11种蒽醌类化合物、2种木脂素类化合物、3种苯丙素类化合物、2种4 -羟基苯乙酯、1种甲氧基苯酚和1种环烯醚萜类化合物。借助包括广泛的二维核磁共振光谱在内的光谱数据确定了新代谢产物的结构。通过将已知化合物的物理和光谱数据与文献报道的数据进行比较来鉴定它们。对这些化合物针对白色念珠菌ATCC 24433、白色念珠菌ATCC 90028、光滑念珠菌ATCC 90030、克鲁斯念珠菌ATCC 6258和近平滑念珠菌ATCC 22019进行了测试。其中一些具有中等活性。

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