Department of Radiology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA, USA.
Clin Nucl Med. 2011 Dec;36(12):1079-85. doi: 10.1097/RLU.0b013e3182336234.
Tc-99m-mebrofenin clearance rate is used to estimate hepatocellular function. This investigation studied effect of labeling-to-administration (LTA) time of Tc-99m-mebrofenin and its liver clearance rate.
A total of 15 patients, age 46 ± 13 (range, 19-69) years, referred for routine gallbladder ejection fraction testing, were retrospectively studied. All had tests associated to normal liver, and no medical history of liver diseases was observed. Tc-99m-mebrofenin scintigraphic liver clearance (MSLC) rate was determined by the standard technique based on liver uptake rate. The radiopharmaceutical was prepared at an off-site central radiopharmacy. Linear regression was used to assess relationship of LTA time and MSLC.
The LTA was 7.6 ± 2.0 (range, 4-12) hours. The labeling efficiency was 99.0% ± 1.33%. The MSLC rate was 11.9%/min ± 2.7%/min (range, 6.4-18.3). There was an inverse relationship of LTA and MSLC, expressed in the following equation: y = -0. 97x + 19.25 (R = 0.5076, P = 0.0028). The negative correlation with LTA remained when MSLC was corrected for body surface area (R = 0.4241, P = 0.0085).
There is a significant underestimation of MSLC with increasing LTA time. If liver function assessment is the purpose of a hepatobiliary study, Tc-99m-mebrofenin should be administered as close to the time of radiopharmaceutical preparation as possible, preferably within 1 hour.
Tc-99m-美罗芬宁清除率用于估计肝细胞功能。本研究探讨了 Tc-99m-美罗芬宁的标记至给药（LTA）时间及其肝脏清除率的影响。
回顾性研究了 15 名年龄 46±13 岁（范围 19-69 岁）的患者，这些患者因常规胆囊排空分数测试而就诊。所有患者均进行了正常肝脏相关检查，且无肝脏疾病病史。Tc-99m-美罗芬宁闪烁肝脏清除率（MSLC）率通过基于肝脏摄取率的标准技术确定。放射性药物在异地中心放射药房制备。线性回归用于评估 LTA 时间和 MSLC 之间的关系。
LTA 为 7.6±2.0 小时（范围 4-12 小时）。标记效率为 99.0%±1.33%。MSLC 率为 11.9%/分钟±2.7%/分钟（范围 6.4-18.3）。LTA 与 MSLC 呈负相关，其关系式为 y=-0.97x+19.25（R=0.5076，P=0.0028）。当 MSLC 按体表面积校正时，与 LTA 的负相关仍然存在（R=0.4241，P=0.0085）。
随着 LTA 时间的增加，MSLC 会被显著低估。如果肝脏功能评估是肝胆研究的目的，那么 Tc-99m-美罗芬宁应尽可能接近放射性药物制备时间给药，最好在 1 小时内。
