Department of Diagnostic and Interventional Radiology, Charité Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany,
Eur Radiol. 2015 May;25(5):1384-91. doi: 10.1007/s00330-014-3536-8. Epub 2014 Dec 2.
To compare Gd-EOB-enhanced MRI and (99m)Tc-mebrofenin hepatobiliary scintigraphy (HBS) as imaging-based liver function tests for separate evaluation of right (RLL) and left liver lobe (LLL) function.
Fourteen patients underwent Gd-EOB-enhanced MRI and (99m)Tc-mebrofenin HBS after portal vein embolization within 24 h. Relative enhancement (RE) and hepatic uptake index (HUI) were determined from MRI; and T max, T 1/2 and mebrofenin uptake were determined from HBS, all values separately for RLL and LLL.
Mebrofenin uptake correlated significantly with HUI and RE for both liver lobes. There was strong correlation of mebrofenin uptake with HUI for RLL (r (2) = 0.802, p = 0.001) and RE for LLL (r (2) = 0.704, p = 0.005) and moderate correlation with HUI for LLL (r (2) = 0.560, p = 0.037) and RE for RLL (r (2) = 0.620, p = 0.018). Correlating the percentage share of RLL function derived from MRI (with HUI) with the percentage of RLL function derived from mebrofenin uptake revealed a strong correlation (r (2) = 0.775, p = 0.002).
Both RE and HUI correlate with mebrofenin uptake in HBS. The results suggest that Gd-EOB-enhanced MRI and (99m)Tc-mebrofenin HBS may equally be used to separately determine right and left liver lobe function.
• Information about liver function can be acquired with routine Gd-EOB-MRI. • Gd-EOB-MRI and (99m) Tc-mebrofenin HBS show elevated function of non-embolized lobe. • Gd-EOB-MRI and (99m) Tc-mebrofenin HBS can determine lobar liver function.
比较钆塞酸二钠增强磁共振成像（Gd-EOB-MRI）和（99m）Tc-美罗芬宁肝胆闪烁扫描（HBS）作为基于影像学的肝功能检测，分别评估右（RLL）和左肝叶（LLL）的功能。
14 例患者在行门静脉栓塞术 24 小时内接受 Gd-EOB-MRI 和（99m）Tc-美罗芬宁 HBS 检查。从 MRI 中确定相对增强（RE）和肝摄取指数（HUI）；从 HBS 中确定 T max、T 1/2 和美罗芬宁摄取，所有值分别用于 RLL 和 LLL。
美罗芬宁摄取与两个肝叶的 HUI 和 RE 均呈显著相关。美罗芬宁摄取与 RLL 的 HUI（r (2) = 0.802，p = 0.001）和 LLL 的 RE（r (2) = 0.704，p = 0.005）之间具有强相关性，与 LLL 的 HUI（r (2) = 0.560，p = 0.037）和 RLL 的 RE（r (2) = 0.620，p = 0.018）之间具有中度相关性。将 MRI（采用 HUI）得出的 RLL 功能百分比与美罗芬宁摄取得出的 RLL 功能百分比进行比较，发现两者具有很强的相关性（r (2) = 0.775，p = 0.002）。
RE 和 HUI 均与 HBS 中美罗芬宁摄取相关。结果表明，Gd-EOB-MRI 和（99m）Tc-美罗芬宁 HBS 均可用于分别确定右肝叶和左肝叶的功能。
常规 Gd-EOB-MRI 可获得肝功能信息。
Gd-EOB-MRI 和（99m）Tc-美罗芬宁 HBS 显示非栓塞叶的功能升高。
Gd-EOB-MRI 和（99m）Tc-美罗芬宁 HBS 可确定肝叶的肝功能。
