Southern Medical University, Guangzhou, China.
Clin Nucl Med. 2011 Dec;36(12):1092-7. doi: 10.1097/RLU.0b013e3182335df4.
F-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET)/computed tomography (CT) alone has limited sensitivity for the diagnosis of hepatocellular carcinoma (HCC). We hoped to improve the diagnostic sensitivity by combining F-18 FDG and C-choline PET/CT.
A total of 76 consecutive patients with HCC were prospectively enrolled. Whole-body F-18 FDG PET/CT scan was performed for all patients. In those patients with negative F-18 FDG scans, a regional C-choline PET/CT scan was also performed.
Positive F-18 FDG scans were noted in 61.1% (48/76) patients with HCC. Increased F-18 FDG uptake correlated with decreased tumor differentiation (P = 0.042). In 28 HCC patients with negative F-18 FDG scans, C-choline scan was positive in 71.4% patients. C-choline scan did not detect any significant difference between well- and moderately differentiated HCC (P = 0.585). Compared with F-18 FDG scan, C-choline scan showed a trend toward an improved detection of well-differentiated HCC (66.7% vs. 35.7%, NS). For detection of moderately differentiated HCC, the sensitivity of C-choline and F-18 FDG PET/CT was similar (85.7% vs. 72.0%, P = 0.648). The dual-tracer modality improved the diagnostic sensitivity of F-18 FDG PET/CT alone from 63.1% to 89.5% (P < 0.001).
F-18 FDG in conjunction with C-choline increases the sensitivity of PET/CT in detecting HCC.
氟-18 氟代脱氧葡萄糖（F-18 FDG）正电子发射断层扫描（PET）/计算机断层扫描（CT）单独用于诊断肝细胞癌（HCC）的敏感性有限。我们希望通过结合 F-18 FDG 和 C-胆碱 PET/CT 来提高诊断的敏感性。
共前瞻性纳入 76 例 HCC 连续患者。对所有患者进行全身 F-18 FDG PET/CT 扫描。在那些 F-18 FDG 扫描阴性的患者中，还进行了局部 C-胆碱 PET/CT 扫描。
61.1%（48/76）的 HCC 患者 F-18 FDG 扫描阳性。F-18 FDG 摄取增加与肿瘤分化程度降低相关（P=0.042）。在 28 例 F-18 FDG 扫描阴性的 HCC 患者中，C-胆碱扫描阳性率为 71.4%。C-胆碱扫描在高分化和中分化 HCC 之间未发现显著差异（P=0.585）。与 F-18 FDG 扫描相比，C-胆碱扫描对高分化 HCC 的检测显示出改善的趋势（66.7%比 35.7%，无统计学意义）。对于中分化 HCC 的检测，C-胆碱和 F-18 FDG PET/CT 的敏感性相似（85.7%比 72.0%，P=0.648）。双示踪剂方法使 F-18 FDG PET/CT 单独检测的敏感性从 63.1%提高到 89.5%（P<0.001）。
F-18 FDG 联合 C-胆碱可提高 PET/CT 检测 HCC 的敏感性。
