Díaz-Ortega J L, Valdespino-Gómez J L, Zárate-Aquino M L, Camacho-Amor M L, González-Velázquez M S, Chávez-San Juan R
Departamento de Investigación Experimental.
Bol Med Hosp Infant Mex. 1990 Jul;47(7):474-81.
Study results of passive natural immunity anti-measles, and immune response to measles vaccine from different strains in Mexican children under one year old, are described in this paper. Mexican infants in these studies ended their maternal immunity at 8-10 months of age. Edmonston-Zagreb (EZ) vaccine strain had higher seroconversion rates comparing to Schwarz strain. Dose response effect was more closely related to Schwarz strain than EZ, since difference in seroconversion rates with standard, medium and high doses were statistically significant. However geometric mean post-vaccination titers were higher in children vaccinated with Schwarz strain, than EZ receptors.
本文描述了墨西哥一岁以下儿童被动自然抗麻疹免疫以及对不同毒株麻疹疫苗免疫反应的研究结果。这些研究中的墨西哥婴儿在8至10个月大时失去了母体免疫力。与施瓦茨毒株相比，埃德蒙斯顿-萨格勒布（EZ）疫苗毒株的血清转化率更高。剂量反应效应与施瓦茨毒株的关系比与EZ毒株的关系更密切，因为标准剂量、中等剂量和高剂量的血清转化率差异具有统计学意义。然而，接种施瓦茨毒株的儿童接种后几何平均滴度高于接种EZ毒株的儿童。
