6月龄婴儿接种AIK-C麻疹疫苗与9月龄婴儿接种施瓦茨疫苗的比较：加纳的一项随机对照试验。
Comparison of AIK-C measles vaccine in infants at 6 months with Schwarz vaccine at 9 months: a randomized controlled trial in Ghana.
作者信息
Nkrumah F K, Osei-Kwasi M, Dunyo S K, Koram K A, Afari E A
机构信息
Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana, Legon, Ghana.
出版信息
Bull World Health Organ. 1998;76(4):353-9.
In a randomized controlled trial in a measles endemic area, standard-dose (4.0 log10pfu) AIK-C measles vaccine administered at 6 months of age was compared to standard-dose Schwarz vaccine (3.7log10pfu) given at 9 months. Seroconversion rates at 3 and 6 months after immunization in the two groups were comparable and similar. The geometric mean titres achieved were, however, significantly higher in the Schwarz group (P < 0.05). No immediate serious side-effects were observed with either vaccine. We conclude that standard-dose AIK-C measles vaccine can be recommended for measles immunization in children below 9 months of age, especially in highly endemic and high-risk areas in developing countries.
在一个麻疹流行地区进行的随机对照试验中，将6月龄时接种的标准剂量（4.0 log10pfu）AIK-C麻疹疫苗与9月龄时接种的标准剂量施瓦茨疫苗（3.7log10pfu）进行了比较。两组免疫后3个月和6个月时的血清转化率相当且相似。然而，施瓦茨组达到的几何平均滴度显著更高（P<0.05）。两种疫苗均未观察到即刻严重副作用。我们得出结论，标准剂量的AIK-C麻疹疫苗可推荐用于9月龄以下儿童的麻疹免疫，特别是在发展中国家的高度流行和高风险地区。
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