Ayala-González M
Departamento de Vacunas Virales, Laboratorio Nacional de Salud Pública, México, D.F.
Bol Med Hosp Infant Mex. 1990 Jul;47(7):512-5.
Production and quality of the vaccines, are important activities in the prevention of measles disease. Edmonston-Zagreb measles vaccine is the main strain attenuated virus distributed in México. In order to evaluate the titer of Edmonston-Zagreb and Schwarz vaccines, 50% tissue culture infective dose (TCID50/0.5 mL) and plaque-forming units (PFU) are performed in the National Laboratory of Public Health. Furthermore PFU is a method used in the stability vaccine test. Validation criteria are described in this paper.
疫苗的生产和质量是预防麻疹疾病的重要活动。埃德蒙斯顿-萨格勒布麻疹疫苗是墨西哥主要分发的减毒病毒株。为了评估埃德蒙斯顿-萨格勒布疫苗和施瓦茨疫苗的效价，在国家公共卫生实验室进行了50%组织培养感染剂量（TCID50/0.5 mL）和空斑形成单位（PFU）检测。此外，PFU是用于疫苗稳定性测试的一种方法。本文描述了验证标准。
