Xiang J Z, Chen Z H
Rev Infect Dis. 1983 May-Jun;5(3):506-10.
The strains of measles virus and the method used in the production of further attenuated live-virus vaccine in the People's Republic of China were studied. Observation of clinical reactions and serologic responses to immunization with Shanghai-191 measles vaccine, which is produced on a large scale with a locally isolated viral strain, revealed that this vaccine is adequately safe and immunogenic. Epidemiologic data showed a significant decrease in measles-associated morbidity after the introduction of mass vaccination in 1965. The duration of immunity induced by Shanghai-191 measles vaccine was studied for eight years in a region in which interference due to natural measles infection had been minimized by mass vaccination of children. Although immunity appeared to persist for at least eight years, the results suggested that primary vaccination does not confer lifelong immunity. Reactions and antibody responses to this vaccine were compared with those to two vaccines from abroad, the Schwarz and Leningrad-16 strains. The hemagglutination-inhibiting (HAI) antibody titer induced by Shanghai-191 vaccine was higher than that induced by Leningrad-16 vaccine and lower than that induced by Schwarz vaccine; however, these differences were not significant. Preliminary studies on the preparation of measles vaccine in human diploid cells have yielded promising results.
对中华人民共和国的麻疹病毒株及用于生产进一步减毒活病毒疫苗的方法进行了研究。对用本地分离的病毒株大规模生产的上海-191麻疹疫苗进行免疫接种后的临床反应和血清学反应观察表明，该疫苗具有足够的安全性和免疫原性。流行病学数据显示，1965年引入大规模疫苗接种后，麻疹相关发病率显著下降。在一个通过对儿童进行大规模疫苗接种使自然麻疹感染干扰降至最低的地区，对上海-191麻疹疫苗诱导的免疫持续时间进行了八年的研究。尽管免疫力似乎至少持续了八年，但结果表明初次接种并不能赋予终身免疫力。将该疫苗的反应和抗体反应与两种国外疫苗（施瓦茨株和列宁格勒-16株）的反应和抗体反应进行了比较。上海-191疫苗诱导的血凝抑制（HAI）抗体滴度高于列宁格勒-16疫苗诱导的滴度，低于施瓦茨疫苗诱导的滴度；然而，这些差异并不显著。用人二倍体细胞制备麻疹疫苗的初步研究已取得了有希望的结果。
