Tamborski A, Lucot J B, Hennessy M B
Department of Psychology, Wright State University, Dayton, Ohio 45435.
Behav Neurosci. 1990 Aug;104(4):607-11. doi: 10.1037//0735-7044.104.4.607.
Guinea pig pups that were separated from their mothers and placed into a novel environment for 90 min showed an increase in dopamine (DA) turnover (ratio of metabolites to DA) in the septum compared with undisturbed baseline controls. Pups placed into the novel environment with their mothers exhibited an intermediate level of DA turnover. After 24 hr of separation in the novel environment, pups' DA turnover in the septum had returned to the baseline level. DA turnover in the caudate nucleus was unaffected by these procedures. Also, turnover in both septum and caudate nucleus when pups were not separated was positively correlated with the number of vocalizations emitted during 30 min of separation. These results closely parallel findings in separated monkeys and indicate that the guinea pig represents a useful rodent model for studying such effects. That elevated DA turnover during separation occurred in the septum suggests involvement of the mesolimbic system.
与未受干扰的基线对照组相比，与母亲分离并置于新环境中90分钟的豚鼠幼崽，其隔区的多巴胺（DA）周转率（代谢物与DA的比率）有所增加。与母亲一起置于新环境中的幼崽表现出中等水平的DA周转率。在新环境中分离24小时后，幼崽隔区的DA周转率已恢复到基线水平。尾状核中的DA周转率不受这些操作的影响。此外，未分离的幼崽在隔区和尾状核中的周转率与分离30分钟内发出的叫声数量呈正相关。这些结果与分离猴子的研究结果非常相似，表明豚鼠是研究此类效应的有用啮齿动物模型。分离期间隔区DA周转率升高表明中脑边缘系统参与其中。
