Department of Paediatric Gastroenterology and Nutrition, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Saudi J Gastroenterol. 2011 Nov-Dec;17(6):414-7. doi: 10.4103/1319-3767.87185.
Ulcerative colitis (UC) is a chronic idiopathic inflammatory disorder of colon. Frequency of UC is gradually increasing over few years worldwide. Prevalence is 35 to 100/100,000 people in USA, 1% of them are infants. UC develops in a genetically predisposed individual with altered intestinal immune response. An eight-month-old girl presented with loose bloody stool, growth failure, and moderate pallor. The girl was diagnosed as a case of UC by colonoscopy and biopsy. Treatment was thereafter started with immunosuppressive drugs. After initial induction therapy with parenteral steroid and infliximab, the patient is now on remission with azathioprine and mesalamine. UC is rare in Bangladesh, especially in children, and it is rarer during infancy. Several conditions like infective colitis, allergic colitis, Meckel's diverticulitis, Crohn's disease, etc. may mimic the features of UC. So, if a child presents with recurrent bloody diarrhea, UC should be considered as differential diagnosis.
溃疡性结肠炎（UC）是一种慢性特发性结肠炎症性疾病。近年来，UC 的发病率在全球范围内呈逐渐上升趋势。在美国，UC 的发病率为 35 至 100/10 万，其中 1%为婴儿。UC 发生于具有肠道免疫反应改变的遗传易感性个体。一名 8 个月大的女孩出现稀便带血、生长发育不良和中度苍白。经结肠镜检查和活检，该女孩被诊断为 UC。此后，开始使用免疫抑制剂进行治疗。经过初始的肠外皮质类固醇和英夫利昔单抗诱导治疗后，患者目前处于缓解状态，使用硫唑嘌呤和美沙拉嗪维持治疗。UC 在孟加拉国很少见，尤其是在儿童中，在婴儿中更为罕见。一些疾病，如感染性结肠炎、过敏性结肠炎、 Meckel 憩室炎、克罗恩病等，可能与 UC 的特征相似。因此，如果儿童出现反复血性腹泻，应考虑将 UC 作为鉴别诊断。
