Rydell R, Wennerberg J
Department of Oto-rhino-laryngology, University Hospital, Lund, Sweden.
Arch Otolaryngol Head Neck Surg. 1990 Oct;116(10):1172-6. doi: 10.1001/archotol.1990.01870100066014.
Patients with squamous cell carcinoma of the head and neck are treated with cisplatin and fluorouracil according to a schedule based on the findings of clinical studies. A similar schedule showed a supra-additive effect in the treatment of xenografted human squamous cell carcinoma of the head and neck. We sought to ascertain whether this schedule was optimal. A single intraperitoneal injection of cisplatin (7.5 mg/kg) was combined with three injections of fluorouracil given during a 24-hour period (total dose, 150 or 80 mg/kg) before, during, or after cisplatin administration. The combined effect of cisplatin and fluorouracil on tumor growth and toxic effects was schedule dependent. Consideration of both toxic effects and tumor growth inhibition, as assessed by reduction of the area under the growth curve, the optimal administration interval was found to be fluorouracil given 3 days after cisplatin administration.
根据临床研究结果制定的方案，对头颈部鳞状细胞癌患者采用顺铂和氟尿嘧啶进行治疗。类似的方案在治疗人源化头颈部鳞状细胞癌异种移植瘤时显示出超相加效应。我们试图确定该方案是否最佳。在顺铂给药前、给药期间或给药后24小时内，单次腹腔注射顺铂（7.5mg/kg）与三次注射氟尿嘧啶（总剂量150或80mg/kg）联合使用。顺铂和氟尿嘧啶对肿瘤生长和毒性作用的联合效应取决于给药方案。综合考虑毒性作用和通过生长曲线下面积减少评估的肿瘤生长抑制情况，发现最佳给药间隔为顺铂给药后3天给予氟尿嘧啶。
