Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75235, USA.
Pediatrics. 2011 Dec;128(6):e1622-7. doi: 10.1542/peds.2010-3823. Epub 2011 Nov 7.
Designer drugs have been problematic over the years. Products such as K2 and Spice, which contain synthetic cannabinoids, are marketed as incense and are widely available on the Internet and at various specialty shops. The effects are reported as cannabis-like after smoking them. In addition, use of these synthetic cannabinoids will not appear on a routine urine toxicology screen. Recently, K2 became a popular alternative to marijuana among youths. Health implications of these designer drugs are not completely understood. Little has been reported about the harmful effects of K2. We report here the first (to our knowledge) cases of myocardial infarction (MI) after smoking K2. Three patients presented separately to the emergency department complaining of chest pain within days after the use of K2. Acute MI was diagnosed in each case on the basis of electrocardiogram changes and elevated troponin levels. Coronary angiography was performed, and the results were normal for the first 2 patients. The incidence of ST-elevation MI is low among teenagers, and association with drug use should be suspected. Public education and awareness need to be heightened about the possible health implications of K2.
多年来，设计毒品一直是个问题。K2 和 Spice 等含有合成大麻素的产品被宣传为熏香，在互联网上和各种专卖店广泛销售。吸食后会产生类似大麻的效果。此外，这些合成大麻素的使用不会出现在常规尿液毒理学筛查中。最近，K2 成为年轻人中吸食大麻的流行替代品。这些设计毒品的健康影响还不完全清楚。关于 K2 的有害影响报道很少。我们在此报告首例（据我们所知）吸食 K2 后发生心肌梗死（MI）的病例。有 3 名患者分别因胸痛到急诊科就诊，均在使用 K2 后几天内出现症状。根据心电图改变和肌钙蛋白水平升高，每位患者均诊断为急性 MI。前 2 例患者的冠状动脉造影结果正常。在青少年中，ST 段抬高型心肌梗死的发病率较低，应怀疑与药物使用有关。需要加强公众对 K2 可能产生的健康影响的教育和认识。
