迟发性运动障碍：超敏反应假说的一项临床检验。
Tardive dyskinesia: a clinical test of the supersensitivity hypothesis.
作者信息
Bowers M B, Moore D, Tarsy D
出版信息
Psychopharmacology (Berl). 1979 Mar 22;61(2):137-41. doi: 10.1007/BF00426727.
PMID:220654
Abstract
Patients with tardive dyskinesia showed no significant difference in CSF HVA when compared with groups of schizophrenic or depressives. CSF cAMP in the tardive dyskinesia group was significantly lower when compared to schizophrenics but not depressives. These results do not support a dopamine-receptor supersensitivity hypothesis in permanent tardive dyskinesia.
摘要
迟发性运动障碍患者与精神分裂症患者或抑郁症患者组相比，脑脊液中高香草酸（HVA）无显著差异。与精神分裂症患者相比，迟发性运动障碍组的脑脊液环磷酸腺苷（cAMP）显著降低，但与抑郁症患者相比则无差异。这些结果不支持永久性迟发性运动障碍中的多巴胺受体超敏假说。
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