迟发性运动障碍超敏反应的神经内分泌研究。
A neuroendocrine study of supersensitivity in tardive dyskinesia.
作者信息
Tamminga C A, Smith R C, Pandey G, Frohman L A, Davis J M
出版信息
Arch Gen Psychiatry. 1977 Oct;34(10):1199-203. doi: 10.1001/archpsyc.1977.01770220081009.
A study of the tuberoinfundibular dopamine tract was undertaken in chronic schizophrenic patients with and without tardive dyskinesia. Biochemical evidence of the purported dopamine receptor supersensitivity in tardive dyskinesia was sought by demonstrating a hyperresponse of growth hormone and prolactin to dopamine agonists. Contrary to this prediction, no endocrine supersensitivity occurred in the tardive dyskinesia patients. Rather, a significantly decreased response to dopaminergic stimulation was demonstrated in the total chronic schizophrenic group.
对患有和未患迟发性运动障碍的慢性精神分裂症患者的结节漏斗多巴胺束进行了一项研究。通过证明生长激素和催乳素对多巴胺激动剂的高反应性，来寻找迟发性运动障碍中所谓多巴胺受体超敏反应的生化证据。与这一预测相反，迟发性运动障碍患者未出现内分泌超敏反应。相反，在整个慢性精神分裂症患者组中，对多巴胺能刺激的反应显著降低。
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