• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

（2,6-二氟苯基）（4-甲基哌啶-1-基）甲酮

(2,6-Difluoro-phen-yl)(4-methyl-piperidin-1-yl)methanone.

作者信息

Al-Dajani Mohammad T M, Adballah Hassan H, Mohamed Nornisah, Hemamalini Madhukar, Fun Hoong-Kun

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2011 Sep 1;67(Pt 9):o2409. doi: 10.1107/S1600536811033848. Epub 2011 Aug 27.

DOI:10.1107/S1600536811033848
PMID:22065411
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3200831/
Abstract

In the title compound, C(13)H(15)F(2)NO, the piperidine ring adopts a chair conformation. The dihedral angle between the least-squares plane of the piperidine ring and the benzene ring is 48.75 (7)°. In the crystal structure, the mol-ecules are connected via C-H⋯O hydrogen bonds, forming a zigzag chain along the b axis.

摘要

在标题化合物C₁₃H₁₅F₂NO中，哌啶环呈椅式构象。哌啶环的最小二乘平面与苯环之间的二面角为48.75 (7)°。在晶体结构中，分子通过C—H⋯O氢键相连，沿b轴形成之字形链。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/218d/3200831/6ac68c65642c/e-67-o2409-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/218d/3200831/b01f3fccd5cd/e-67-o2409-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/218d/3200831/6ac68c65642c/e-67-o2409-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/218d/3200831/b01f3fccd5cd/e-67-o2409-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/218d/3200831/6ac68c65642c/e-67-o2409-fig2.jpg

相似文献

1
(2,6-Difluoro-phen-yl)(4-methyl-piperidin-1-yl)methanone.（2,6-二氟苯基）（4-甲基哌啶-1-基）甲酮
Acta Crystallogr Sect E Struct Rep Online. 2011 Sep 1;67(Pt 9):o2409. doi: 10.1107/S1600536811033848. Epub 2011 Aug 27.
2
Crystal structure of (4-chloro-phen-yl)(4-methyl-piperidin-1-yl)methanone.（4-氯苯基）（4-甲基哌啶-1-基）甲酮的晶体结构
Acta Crystallogr E Crystallogr Commun. 2020 Mar 13;76(Pt 4):534-538. doi: 10.1107/S2056989020001930. eCollection 2020 Apr 1.
3
(2,3-Difluoro-phen-yl)(4-tosyl-piperazin-1-yl)methanone.（2,3-二氟苯基）（4-甲苯磺酰基哌嗪-1-基）甲酮
Acta Crystallogr Sect E Struct Rep Online. 2013 Feb 1;69(Pt 2):o185. doi: 10.1107/S1600536812051690. Epub 2013 Jan 4.
4
(2E)-3-(3-Nitro-phen-yl)-1-[4-(piperidin-1-yl)phen-yl]prop-2-en-1-one.（2E）-3-（3-硝基苯基）-1-[4-（哌啶-1-基）苯基]丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2012 Apr 1;68(Pt 4):o974. doi: 10.1107/S1600536812008847. Epub 2012 Mar 7.
5
4-[(E)-(2,4-Difluoro-phen-yl)(hydroxy-imino)meth-yl]piperidinium picrate.4-[(E)-(2,4-二氟苯基)(羟基亚氨基)甲基]哌啶鎓苦味酸盐
Acta Crystallogr Sect E Struct Rep Online. 2009 Sep 5;65(Pt 10):o2365-6. doi: 10.1107/S1600536809035363.
6
3-(4-Chloro-benzo-yl)-4-(4-chloro-phen-yl)-1-phenethyl-piperidin-4-ol.3-（4-氯-苯甲酰基）-4-（4-氯-苯基）-1-苯乙基-哌啶-4-醇
Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 1;67(Pt 6):o1447-8. doi: 10.1107/S1600536811018034. Epub 2011 May 20.
7
Crystal structure of 3-methyl-2,6-bis-(4-methyl-1,3-thia-zol-5-yl)piperidin-4-one.3-甲基-2,6-双-（4-甲基-1,3-噻唑-5-基）哌啶-4-酮的晶体结构
Acta Crystallogr Sect E Struct Rep Online. 2014 Aug 30;70(Pt 9):o1055. doi: 10.1107/S1600536814018856. eCollection 2014 Sep 1.
8
N-(2-{[5-Bromo-2-(piperidin-1-yl)pyrimidin-4-yl]sulfan-yl}-4-meth-oxy-phen-yl)-4-methyl-benzene-sulfonamide.N-（2-{[5-溴-2-（哌啶-1-基）嘧啶-4-基]硫烷基}-4-甲氧基苯基）-4-甲基苯磺酰胺
Acta Crystallogr Sect E Struct Rep Online. 2012 Oct 1;68(Pt 10):o2831. doi: 10.1107/S1600536812037257. Epub 2012 Sep 1.
9
Crystal structure of (4-hy-droxy-piperidin-1-yl)(4-methyl-phen-yl)methanone.（4-羟基哌啶-1-基）（4-甲基苯基）甲酮的晶体结构
Acta Crystallogr E Crystallogr Commun. 2015 Oct 3;71(Pt 11):o817-8. doi: 10.1107/S2056989015018307. eCollection 2015 Nov 1.
10
N-(2-{[5-Bromo-2-(piperidin-1-yl)pyrimidin-4-yl]sulfan-yl}-4-meth-oxy-phen-yl)-2,4,6-trimethyl-benzene-sulfonamide.N-（2-{[5-溴-2-（哌啶-1-基）嘧啶-4-基]硫基}-4-甲氧基苯基）-2,4,6-三甲基苯磺酰胺
Acta Crystallogr Sect E Struct Rep Online. 2012 Sep 1;68(Pt 9):o2767. doi: 10.1107/S1600536812036185. Epub 2012 Aug 25.

本文引用的文献

1
Structure validation in chemical crystallography.化学晶体学中的结构验证
Acta Crystallogr D Biol Crystallogr. 2009 Feb;65(Pt 2):148-55. doi: 10.1107/S090744490804362X. Epub 2009 Jan 20.
2
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
3
Syntheses, activity and modeling studies of 3- and 4-(sulfo- and sulfonamidoalkyl)pyridine and piperidine-2-carboxylic acid derivatives as analogs of NMDA receptor antagonists.
作为NMDA受体拮抗剂类似物的3-和4-（磺基和磺酰胺基烷基）吡啶及哌啶-2-羧酸衍生物的合成、活性及建模研究
Bioorg Med Chem. 1995 Sep;3(9):1183-201. doi: 10.1016/0968-0896(95)00087-w.
4
Binding properties of nine 4-diphenyl-acetoxy-N-methyl-piperidine (4-DAMP) analogues to M1, M2, M3 and putative M4 muscarinic receptor subtypes.九种4-二苯基乙酰氧基-N-甲基哌啶（4-DAMP）类似物与M1、M2、M3及假定的M4毒蕈碱受体亚型的结合特性。
Br J Pharmacol. 1992 Jan;105(1):97-102. doi: 10.1111/j.1476-5381.1992.tb14217.x.