• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

2 - [(1R,3S) - 6,7 - 二甲氧基 - 1 - 苯基 - 1,2,3,4 - 四氢异喹啉 - 3 - 基] - 4 - 苯基 - 1,3 - 噻唑

2-[(1R,3S)-6,7-Dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinolin-3-yl]-4-phenyl-1,3-thia-zole.

作者信息

Pawar Sunayna, Katharigatta Venugopala, Govender Thavendran, Kruger Hendrik G, Maguire Glenn E M

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2011 Oct 1;67(Pt 10):o2722. doi: 10.1107/S1600536811037494. Epub 2011 Sep 30.

DOI:10.1107/S1600536811037494
PMID:22065627
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3201443/
Abstract

In the title compound, C(26)H(24)N(2)O(2)S, the dihedral angle between the thia-zole ring and the adjacent phenyl ring is 3.02 (15)°. The N-containing six-membered ring of the tetra-hydro-isoquinoline unit adopts a half-chair conformation. The dihedral angle between the least-squares plane of the tetra-hydro-isoquinoline ring system and its nearest phenyl ring is 76.90 (13)°. No classical hydrogen bonds nor π-π inter-actions were found in the crystal structure.

摘要

在标题化合物C(26)H(24)N(2)O(2)S中，噻唑环与相邻苯环之间的二面角为3.02 (15)°。四氢异喹啉单元的含氮六元环呈半椅式构象。四氢异喹啉环系的最小二乘平面与其最近的苯环之间的二面角为76.90 (13)°。在晶体结构中未发现经典氢键和π-π相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8851/3201443/a224f6ea0099/e-67-o2722-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8851/3201443/a224f6ea0099/e-67-o2722-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8851/3201443/a224f6ea0099/e-67-o2722-fig1.jpg

相似文献

1
2-[(1R,3S)-6,7-Dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinolin-3-yl]-4-phenyl-1,3-thia-zole.2 - [(1R,3S) - 6,7 - 二甲氧基 - 1 - 苯基 - 1,2,3,4 - 四氢异喹啉 - 3 - 基] - 4 - 苯基 - 1,3 - 噻唑
Acta Crystallogr Sect E Struct Rep Online. 2011 Oct 1;67(Pt 10):o2722. doi: 10.1107/S1600536811037494. Epub 2011 Sep 30.
2
(S)-4-tert-Butyl-2-(1,2,3,4-tetra-hydro-isoquinolin-3-yl)-1,3-thia-zole.（S）-4-叔丁基-2-（1,2,3,4-四氢异喹啉-3-基）-1,3-噻唑
Acta Crystallogr Sect E Struct Rep Online. 2012 Aug 1;68(Pt 8):o2487. doi: 10.1107/S160053681203173X. Epub 2012 Jul 18.
3
[(1R,3S)-6,7-Dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinolin-3-yl]methanol 2.33-hydrate.[(1R,3S)-6,7-二甲氧基-1-苯基-1,2,3,4-四氢异喹啉-3-基]甲醇2.33水合物
Acta Crystallogr Sect E Struct Rep Online. 2011 Feb 23;67(Pt 3):o700. doi: 10.1107/S1600536811006052.
4
{(1R,3S)-2-Benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinolin-3-yl}diphenyl-methanol.{(1R,3S)-2-苄基-6,7-二甲氧基-1-苯基-1,2,3,4-四氢异喹啉-3-基}二苯基甲醇
Acta Crystallogr Sect E Struct Rep Online. 2010 Feb 17;66(Pt 3):o638. doi: 10.1107/S1600536810005295.
5
4-[(2,5-Dimethyl-1,3-thia-zol-4-yl)meth-yl]-4-hydr-oxy-2-methyl-isoquinoline-1,3(2H,4H)-dione.4-[(2,5-二甲基-1,3-噻唑-4-基)甲基]-4-羟基-2-甲基异喹啉-1,3(2H,4H)-二酮
Acta Crystallogr Sect E Struct Rep Online. 2010 Mar 27;66(Pt 4):o964-5. doi: 10.1107/S1600536810011141.
6
4-[(2,4-Dimethyl-thia-zol-5-yl)meth-yl]-4-hydr-oxy-2-methyl-isoquinoline-1,3(2H,4H)-dione.4-[(2,4-二甲基-噻唑-5-基)甲基]-4-羟基-2-甲基异喹啉-1,3(2H,4H)-二酮
Acta Crystallogr Sect E Struct Rep Online. 2010 Mar 27;66(Pt 4):o940-1. doi: 10.1107/S1600536810010469.
7
(S)-4-Phenyl-2-(1,2,3,4-tetra-hydro-isoquinolin-3-yl)-1,3-thia-zole.（S）-4-苯基-2-（1,2,3,4-四氢异喹啉-3-基）-1,3-噻唑
Acta Crystallogr Sect E Struct Rep Online. 2012 Jan;68(Pt 1):o176. doi: 10.1107/S1600536811052585. Epub 2011 Dec 21.
8
3-Benzyl-7-meth-oxy-9-phenyl-2-tosyl-2,3,3a,4,9,9a-hexa-hydro-1H-pyrrolo[3,4-b]quinoline.3-苄基-7-甲氧基-9-苯基-2-对甲苯磺酰基-2,3,3a,4,9,9a-六氢-1H-吡咯并[3,4-b]喹啉
Acta Crystallogr Sect E Struct Rep Online. 2009 Oct 31;65(Pt 11):o2956-7. doi: 10.1107/S1600536809044973.
9
2-Methyl-1,2,3,4-tetra-hydro-isoquinolin-6-yl N-phenyl-carbamate.2-甲基-1,2,3,4-四氢异喹啉-6-基 N-苯基氨基甲酸酯
Acta Crystallogr Sect E Struct Rep Online. 2009 Apr 18;65(Pt 5):o1058. doi: 10.1107/S1600536809013415.
10
(1S,3S)-Methyl 6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate.（1S，3S）-6,7-二甲氧基-1-苯基-1,2,3,4-四氢异喹啉-3-羧酸甲酯
Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 1;67(Pt 6):o1501. doi: 10.1107/S1600536811018782. Epub 2011 May 25.

引用本文的文献

1
Crystal structure and Hirshfeld surface analysis of 3-amino-1-oxo-2,6,8-triphenyl-1,2,7,8-tetra-hydro-iso-quinoline-4-carbo-nitrile.3-氨基-1-氧代-2,6,8-三苯基-1,2,7,8-四氢异喹啉-4-甲腈的晶体结构与 Hirshfeld 表面分析
Acta Crystallogr E Crystallogr Commun. 2021 Jan 29;77(Pt 2):195-199. doi: 10.1107/S2056989021000785. eCollection 2021 Feb 1.
2
(S)-4-tert-Butyl-2-(1,2,3,4-tetra-hydro-isoquinolin-3-yl)-1,3-thia-zole.（S）-4-叔丁基-2-（1,2,3,4-四氢异喹啉-3-基）-1,3-噻唑
Acta Crystallogr Sect E Struct Rep Online. 2012 Aug 1;68(Pt 8):o2487. doi: 10.1107/S160053681203173X. Epub 2012 Jul 18.

本文引用的文献

1
(1S,3S)-Methyl 2-benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate.(1S,3S)-2-苄基-6,7-二甲氧基-1-苯基-1,2,3,4-四氢异喹啉-3-羧酸甲酯
Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 1;67(Pt 6):o1403. doi: 10.1107/S1600536811017430. Epub 2011 May 14.
2
(S)-N-Benzyl-2-methyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxamide.(S)-N-苄基-2-甲基-1,2,3,4-四氢异喹啉-3-甲酰胺
Acta Crystallogr Sect E Struct Rep Online. 2010 Dec 11;67(Pt 1):o67. doi: 10.1107/S1600536810050361.
3
A short history of SHELX.
SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.