• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

2 -（2 - 羟基苯基）- 3,4 - 二氢异喹啉 - 1（2H）- 酮

2-(2-Hy-droxy-phen-yl)-3,4-dihydro-iso-quinolin-1(2H)-one.

作者信息

Yang Jian, Ma Yanni, Pan Meng, Cao Fangjun, Zhou Le

机构信息

College of Science, Northwest Agriculture and Forest University, Yangling 712100, People's Republic of China.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2011 Oct 1;67(Pt 10):o2721. doi: 10.1107/S160053681103710X. Epub 2011 Sep 30.

DOI:10.1107/S160053681103710X
PMID:22065631
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3201540/
Abstract

There are two independent mol-ecules in the asymmetric unit of the title compound, C(15)H(13)NO(2), in both the six-membered dihydro-pyridine rings adopt a half-chair conformation. The two benzene rings make dihedral angles of 43.66 (10) and 62.22 (10)° in the two mol-ecules. In the crystal, the two independent mol-ecules are linked alternately by inter-molecular O-H⋯O hydrogen bonds, forming a zigzag chain along the c axis. Furthermore, inter-molecular C-H⋯π inter-actions link the chains into a three-dimensional network.

摘要

标题化合物C(15)H(13)NO(2)的不对称单元中有两个独立分子，六元二氢吡啶环均呈半椅式构象。两个苯环在两个分子中的二面角分别为43.66 (10)°和62.22 (10)°。在晶体中，两个独立分子通过分子间O-H⋯O氢键交替连接，沿c轴形成之字形链。此外，分子间C-H⋯π相互作用将这些链连接成三维网络。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc3/3201540/630a0302b46f/e-67-o2721-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc3/3201540/877281c24cc8/e-67-o2721-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc3/3201540/630a0302b46f/e-67-o2721-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc3/3201540/877281c24cc8/e-67-o2721-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fc3/3201540/630a0302b46f/e-67-o2721-fig2.jpg

相似文献

1
2-(2-Hy-droxy-phen-yl)-3,4-dihydro-iso-quinolin-1(2H)-one.2 -（2 - 羟基苯基）- 3,4 - 二氢异喹啉 - 1（2H）- 酮
Acta Crystallogr Sect E Struct Rep Online. 2011 Oct 1;67(Pt 10):o2721. doi: 10.1107/S160053681103710X. Epub 2011 Sep 30.
2
Diisobutyl 4-(3-eth-oxy-4-hy-droxy-phen-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxyl-ate.4-(3-乙氧基-4-羟基苯基)-2,6-二甲基-1,4-二氢吡啶-3,5-二羧酸二异丁酯
Acta Crystallogr Sect E Struct Rep Online. 2012 Feb 1;68(Pt 2):o287-8. doi: 10.1107/S1600536811055334. Epub 2012 Jan 7.
3
4-Hy-droxy-3-[(4-hy-droxy-6-methyl-2-oxo-3,6-dihydro-2H-pyran-3-yl)(3-thien-yl)meth-yl]-6-methyl-3,6-dihydro-2H-pyran-2-one.4-羟基-3-[(4-羟基-6-甲基-2-氧代-3,6-二氢-2H-吡喃-3-基)(3-噻吩基)甲基]-6-甲基-3,6-二氢-2H-吡喃-2-酮
Acta Crystallogr Sect E Struct Rep Online. 2011 Jan 26;67(Pt 2):o494-5. doi: 10.1107/S1600536811002716.
4
1-[5-(4-Chloro-phen-yl)-3-(4-hy-droxy-phen-yl)-4,5-dihydro-1H-pyrazol-1-yl]-ethanone.1-[5-(4-氯苯基)-3-(4-羟基苯基)-4,5-二氢-1H-吡唑-1-基]乙酮
Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 1;68(Pt 3):o818. doi: 10.1107/S1600536812006885. Epub 2012 Feb 24.
5
rac-6-Hy-droxy-4-(4-nitro-phen-yl)-5-(2-thienyl-carbon-yl)-6-(trifluoro-meth-yl)-3,4,5,6-tetra-hydro-pyrimidin-2(1H)-one monohydrate.
Acta Crystallogr Sect E Struct Rep Online. 2010 Oct 23;66(Pt 11):o2932-3. doi: 10.1107/S1600536810041589.
6
5-[(E)-2-Fluoro-benzyl-idene]-8-(2-fluoro-phen-yl)-2-hy-droxy-10-methyl-3,10-di-aza-hexa-cyclo-[10.7.1.1.0.0.0]henicosa-1(20),12,14,16,18-pentaen-6-one.5-[(E)-2-氟-亚苄基]-8-(2-氟-苯基)-2-羟基-10-甲基-3,10-二氮杂-六环-[10.7.1.1.0.0.0]二十一碳-1(20),12,14,16,18-五烯-6-酮
Acta Crystallogr Sect E Struct Rep Online. 2010 Dec 24;67(Pt 1):o211-2. doi: 10.1107/S1600536810052815.
7
(E)-1-[4-(Hex-yloxy)phen-yl]-3-(3-hy-droxy-phen-yl)prop-2-en-1-one.（E）-1-[4-（己氧基）苯基]-3-（3-羟基苯基）丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2010 Nov 24;66(Pt 12):o3275-6. doi: 10.1107/S1600536810047768.
8
10-(6-Hy-droxy-hexa-2,4-diyn-1-yl)-10H-phenothia-zine 5-oxide.10 -（6 - 羟基 - 己 - 2,4 - 二炔 - 1 - 基）- 10H - 吩噻嗪5 - 氧化物
Acta Crystallogr Sect E Struct Rep Online. 2012 Jul 1;68(Pt 7):o2214. doi: 10.1107/S1600536812027511. Epub 2012 Jun 27.
9
(E)-1-(2-Amino-phen-yl)-3-(3,4,5-trimeth-oxy-phen-yl)prop-2-en-1-one.（E）-1-（2-氨基苯基）-3-（3,4,5-三甲氧基苯基）丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2011 Sep 1;67(Pt 9):o2485-6. doi: 10.1107/S1600536811033861. Epub 2011 Aug 27.
10
3-Hy-droxy-1-methyl-2-[4-(piperidin-1-yl)phen-yl]quinolin-4(1H)-one.3-羟基-1-甲基-2-[4-(哌啶-1-基)苯基]喹啉-4(1H)-酮
Acta Crystallogr Sect E Struct Rep Online. 2011 Feb 19;67(Pt 3):o654. doi: 10.1107/S1600536811005046.

本文引用的文献

1
Synthesis and biological activity of pyrazolothienotetrahydroisoquinoline and [1,2,4]triazolo[3,4-a]thienotetrahydroisoquinoline derivatives.吡唑并噻吩并四氢异喹啉和[1,2,4]三唑并[3,4-a]噻吩并四氢异喹啉衍生物的合成与生物活性。
Eur J Med Chem. 2011 Feb;46(2):567-78. doi: 10.1016/j.ejmech.2010.11.036. Epub 2010 Dec 1.
2
Cytotoxic activity of sanguinarine and dihydrosanguinarine in human promyelocytic leukemia HL-60 cells.血根碱和二氢血根碱对人早幼粒细胞白血病HL-60细胞的细胞毒性活性。
Toxicol In Vitro. 2009 Jun;23(4):580-8. doi: 10.1016/j.tiv.2009.01.016. Epub 2009 Feb 3.
3
Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4,5-dihydro-1H-pyrazol-5-yl)-7-substitued-1,2,3,4-tetrahydroisoquinoline derivatives.
新型2-(1-(2-(取代苯基)-5-甲基恶唑-4-基)-3-(2-取代苯基)-4,5-二氢-1H-吡唑-5-基)-7-取代-1,2,3,4-四氢异喹啉衍生物的合成、结构及抗菌活性
Bioorg Med Chem. 2009 Feb 1;17(3):1207-13. doi: 10.1016/j.bmc.2008.12.034. Epub 2008 Dec 24.
4
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
5
Synthesis and neurotoxicity of tetrahydroisoquinoline derivatives for studying Parkinson's disease.用于研究帕金森病的四氢异喹啉衍生物的合成与神经毒性
Biol Pharm Bull. 2005 Aug;28(8):1355-62. doi: 10.1248/bpb.28.1355.
6
Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery.血根碱通过调节细胞周期蛋白激酶抑制剂-细胞周期蛋白-细胞周期蛋白依赖性激酶机制，导致人前列腺癌细胞的细胞周期阻滞和凋亡。
Mol Cancer Ther. 2004 Aug;3(8):933-40.
7
Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: studies using heterologous expression systems of the dopamine transporter.与帕金森病相关的异喹啉衍生物的选择性多巴胺能神经毒性：利用多巴胺转运体异源表达系统的研究
Biochem Pharmacol. 2002 Mar 1;63(5):909-20. doi: 10.1016/s0006-2952(01)00922-4.