Walsh Alexandra M, Fiveash John B, Reddy Alyssa T, Friedman Gregory K
Division of Pediatric Hematology Oncology, University of Alabama at Birmingham, Birmingham, AL;
Rare Tumors. 2011 Jul 11;3(3):e32. doi: 10.4081/rt.2011.e32. Epub 2011 Jul 21.
Renal medullary carcinoma (RMC) is a rare and highly aggressive malignancy arising from the renal medulla and found mostly in patients with sickle cell trait. RMC usually presents with widely metastatic disease. We describe a young man diagnosed with metastatic RMC who sustained a complete response to systemic chemotherapy but developed brain metastases with leptomeningeal involvement and subsequently had a partial response to brain irradiation. The use of radiation in the management of RMC is reviewed. Due to the apparent propensity for RMC to spread to the central nervous system, prophylactic treatment such as craniospinal irradiation should be considered along with chemotherapy in patients with metastatic RMC to potentially improve the progression-free interval.
肾髓质癌（RMC）是一种罕见且侵袭性很强的恶性肿瘤，起源于肾髓质，多见于具有镰状细胞特征的患者。RMC通常表现为广泛转移的疾病。我们描述了一名被诊断为转移性RMC的年轻男性，他对全身化疗产生了完全缓解，但出现了伴有软脑膜受累的脑转移，随后对脑部放疗产生了部分缓解。本文回顾了放疗在RMC治疗中的应用。鉴于RMC明显有扩散至中枢神经系统的倾向，对于转移性RMC患者，在化疗的同时应考虑进行预防性治疗，如全脑脊髓放疗，以潜在地改善无进展生存期。
