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细胞质磷脂酶A2在结直肠癌患者中的预后意义

Prognostic significance of cytosolic phospholipase A2 expression in patients with colorectal cancer.

作者信息

Yoo Young Sun, Lim Sung Chul, Kim Kyung Jong

机构信息

Department of Surgery, Chosun University College of Medicine, Gwangju, Korea.

出版信息

J Korean Surg Soc. 2011 Jun;80(6):397-403. doi: 10.4174/jkss.2011.80.6.397. Epub 2011 Jun 9.

DOI:10.4174/jkss.2011.80.6.397
PMID:22066066
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3204686/
Abstract

PURPOSE

Cyclooxygenase-2 is believed to be an important enzyme in the pathogenesis of colorectal cancer (CRC). Cytosolic phospholipase A2 (cPLA2), also, have been suggested to be related to the carcinogenesis of CRC. The aim of this study was to investigate cPLA2 expression and its relationship with prognostic significance in CRC.

METHODS

Eighty-eight patients with colorectal cancer who underwent curative surgery were enrolled in this study. cPLA2 was examined in 88 primary CRCs by immunohistochemistry and we compared their expression with clinicopathologic findings, recurrence and survival in patients with CRC.

RESULTS

The expression of cPLA2 was positive in 54.5% (48/88). The expression of cPLA2 was not correlated with clinicopathologic parameters. However, cPLA2 expression was significantly related with vascular endothelial growth factor expression. Kaplan-Meier analysis didn't show any clinical significance in disease-free survival and overall survival according to cPLA2 expression.

CONCLUSION

These results suggest that cPLA2 expression was not associated with the prognosis of CRC. However, further large-scale studies are needed to clarify the prognostic effect of cPLA2 in CRC.

摘要

目的

环氧合酶-2被认为是结直肠癌（CRC）发病机制中的一种重要酶。胞质型磷脂酶A2（cPLA2）也被认为与CRC的致癌作用有关。本研究的目的是调查cPLA2在CRC中的表达及其与预后意义的关系。

方法

本研究纳入了88例行根治性手术的结直肠癌患者。通过免疫组织化学检测88例原发性CRC中的cPLA2，并将其表达与CRC患者的临床病理特征、复发和生存情况进行比较。

结果

cPLA2的表达在54.5%（48/88）的病例中呈阳性。cPLA2的表达与临床病理参数无关。然而，cPLA2表达与血管内皮生长因子表达显著相关。根据cPLA2表达情况进行的Kaplan-Meier分析在无病生存期和总生存期方面未显示出任何临床意义。

结论

这些结果表明，cPLA2表达与CRC的预后无关。然而，需要进一步的大规模研究来阐明cPLA2在CRC中的预后作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1229/3204686/245cf36ef82c/jkss-80-397-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1229/3204686/e393d79ee7a8/jkss-80-397-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1229/3204686/245cf36ef82c/jkss-80-397-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1229/3204686/e393d79ee7a8/jkss-80-397-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1229/3204686/245cf36ef82c/jkss-80-397-g002.jpg

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本文引用的文献

1
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Yonsei Med J. 2010 Sep;51(5):692-9. doi: 10.3349/ymj.2010.51.5.692.
2
PLA2 (group IIA phospholipase A2) as a prognostic determinant in stage II colorectal carcinoma.PLA2（IIA组磷脂酶A2）作为II期结直肠癌的预后决定因素。
Ann Oncol. 2009 Jul;20(7):1230-5. doi: 10.1093/annonc/mdn783. Epub 2009 Mar 10.
3
Prognostic significance of vascular endothelial growth factor expression and microvessel density in esophageal squamous cell carcinoma: comparison with positron emission tomography.
IV 组磷脂酶 A2 表达减少与胃癌患者预后不良有关。
Med Oncol. 2013 Mar;30(1):454. doi: 10.1007/s12032-012-0454-y. Epub 2013 Jan 10.
血管内皮生长因子表达和微血管密度在食管鳞状细胞癌中的预后意义：与正电子发射断层扫描的比较
Ann Surg Oncol. 2006 Aug;13(8):1054-62. doi: 10.1245/ASO.2006.08.012. Epub 2006 Jul 24.
4
Cytoplasmic phospholipase A2 expression in human colon adenocarcinoma is correlated with cyclooxygenase-2 expression and contributes to prostaglandin E2 production.细胞质磷脂酶A2在人结肠腺癌中的表达与环氧化酶-2的表达相关，并促进前列腺素E2的产生。
Cancer Lett. 2006 Nov 18;243(2):255-63. doi: 10.1016/j.canlet.2005.11.045. Epub 2006 Feb 3.
5
Cytoplasmic phospholipase A2 deletion enhances colon tumorigenesis.
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6
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7
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8
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10
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