Koca Bülent, Kasapçopur Ozgür, Bakari Süleyman, Sönmez Emine, Oztunç Funda, Eroğlu Ayşe Güler, Saltik Levent, Calay Ozden
Department of Pediatric Cardiology, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey.
Cardiol Young. 2012 Aug;22(4):404-9. doi: 10.1017/S1047951111001867. Epub 2011 Nov 9.
Familial Mediterranean fever is a hereditary disease characterised by recurrent and self-terminated attacks of fever and polyserositis. An earlier study found that adult patients of Familial Mediterranean fever had an abnormally longer QT dispersion and corrected QT dispersion, markers for ventricular arrhythmogenicity. QT dispersion is a simple non-invasive arrhythmogenic marker that can be used to assess homogeneity of cardiac repolarisation; however, it has not been studied in children with Familial Mediterranean fever before. The aim of this study was to assess QT dispersion and corrected QT dispersion, and their relationship with systolic and diastolic function of the left ventricle in a group of children with Familial Mediterranean fever. We performed electrocardiography and Doppler echocardiography on patients and controls. Maximum QT, minimum QT, QT dispersion, corrected QT, maximum corrected QT, minimum corrected QT, and corrected QT dispersion intervals were measured from standard 12-lead electrocardiography. No statistically significant differences were found between the groups in QT dispersion, corrected QT dispersion, and systolic-diastolic function of the left ventricle parameters. During the 12 months of follow-up, no ventricular arrhythmias were documented in either group.
家族性地中海热是一种遗传性疾病，其特征为发热和多浆膜炎反复发作且能自行终止。一项较早的研究发现，家族性地中海热的成年患者QT离散度和校正QT离散度异常延长，这是心室致心律失常性的指标。QT离散度是一种简单的非侵入性致心律失常标志物，可用于评估心脏复极的均匀性；然而，此前尚未在家族性地中海热儿童中进行过研究。本研究的目的是评估一组家族性地中海热儿童的QT离散度和校正QT离散度，以及它们与左心室收缩和舒张功能的关系。我们对患者和对照组进行了心电图和多普勒超声心动图检查。从标准12导联心电图测量最大QT、最小QT、QT离散度、校正QT、最大校正QT、最小校正QT和校正QT离散度间期。两组在QT离散度、校正QT离散度和左心室收缩-舒张功能参数方面未发现统计学上的显著差异。在12个月的随访期间，两组均未记录到室性心律失常。
