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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Herrstedt J, Jørgensen M, Angelo H R

Department of Internal Medicine C, Bispebjerg Hospital, University of Copenhagen, Denmark.

Br J Clin Pharmacol. 1990 Aug;30(2):237-43. doi: 10.1111/j.1365-2125.1990.tb03770.x.

Six healthy volunteers were given single oral doses of the antiemetic metopimazine (MPZ), starting with trial (a) 20 mg preprandially and followed by trial (b) 50 mg preprandially. In trials (c) and (d) the doses were similar to those in trials (a) and (b), but MPZ was given postprandially. To evaluate intra-individual variation in serum concentrations, trial (a) was repeated three times in four of the volunteers (trial (e)). 2. Blood samples were drawn and the serum concentrations of MPZ and its acid metabolite (AMPZ) were measured by h.p.l.c. 3. There was no evidence of dose-dependent kinetics at the dose levels studied. 4. Median AUC values were 22.6, 16.2, 52.4 and 35.2 (trials (a), (b), (c) and (d), ng ml-1 h). Food intake decreased the serum concentrations of MPZ, suggesting that MPZ should be taken preprandially.

六名健康志愿者分别单次口服抗吐药美托哌丙嗪（MPZ），起始为试验（a），餐前服用20毫克，随后是试验（b），餐前服用50毫克。在试验（c）和（d）中，剂量与试验（a）和（b）相似，但MPZ于餐后服用。为评估个体血清浓度的差异，试验（a）在四名志愿者中重复进行了三次（试验（e））。2. 采集血样，通过高效液相色谱法测定MPZ及其酸性代谢物（AMPZ）的血清浓度。3. 在研究的剂量水平上，没有剂量依赖性动力学的证据。4. 中位曲线下面积值分别为22.6、16.2、52.4和35.2（试验（a）、（b）、（c）和（d），纳克/毫升·小时）。食物摄入降低了MPZ的血清浓度，表明MPZ应在餐前服用。

Herrstedt J, Jørgensen M, Angelo H R

Department of Internal Medicine C, Bispebjerg Hospital, University of Copenhagen, Denmark.

Br J Clin Pharmacol. 1990 Aug;30(2):237-43. doi: 10.1111/j.1365-2125.1990.tb03770.x.

Six healthy volunteers were given single oral doses of the antiemetic metopimazine (MPZ), starting with trial (a) 20 mg preprandially and followed by trial (b) 50 mg preprandially. In trials (c) and (d) the doses were similar to those in trials (a) and (b), but MPZ was given postprandially. To evaluate intra-individual variation in serum concentrations, trial (a) was repeated three times in four of the volunteers (trial (e)). 2. Blood samples were drawn and the serum concentrations of MPZ and its acid metabolite (AMPZ) were measured by h.p.l.c. 3. There was no evidence of dose-dependent kinetics at the dose levels studied. 4. Median AUC values were 22.6, 16.2, 52.4 and 35.2 (trials (a), (b), (c) and (d), ng ml-1 h). Food intake decreased the serum concentrations of MPZ, suggesting that MPZ should be taken preprandially.

六名健康志愿者分别单次口服抗吐药美托哌丙嗪（MPZ），起始为试验（a），餐前服用20毫克，随后是试验（b），餐前服用50毫克。在试验（c）和（d）中，剂量与试验（a）和（b）相似，但MPZ于餐后服用。为评估个体血清浓度的差异，试验（a）在四名志愿者中重复进行了三次（试验（e））。2. 采集血样，通过高效液相色谱法测定MPZ及其酸性代谢物（AMPZ）的血清浓度。3. 在研究的剂量水平上，没有剂量依赖性动力学的证据。4. 中位曲线下面积值分别为22.6、16.2、52.4和35.2（试验（a）、（b）、（c）和（d），纳克/毫升·小时）。食物摄入降低了MPZ的血清浓度，表明MPZ应在餐前服用。