Barry R E
Gut. 1974 Jul;15(7):562-70. doi: 10.1136/gut.15.7.562.
The mucosal architecture and mucosal dynamics of the small bowel have been studied in patients with malignant disease not of the gastrointestinal tract but associated with severe weight loss. Mucosal changes in malignant disease are demonstrated by stereomicroscopy, mucosal architectural measurement, and decreased lactose utilization. Measurement of the epithelial DNA loss rate indicates, in association with mucosal measurement, that the architectural changes are caused by a hypoplasia of the epithelium. Similar findings are demonstrated in patients with profound weight loss due to other non-malignant wasting diseases. Although mucosal changes undoubtedly occur in malignant disease, the changes are not specific for malignancy and the concept of ;cancer enteropathy' is not tenable. It is suggested that mucosal changes are the effect of and not the cause of cachexia.
对非胃肠道恶性疾病但伴有严重体重减轻的患者的小肠黏膜结构和黏膜动力学进行了研究。恶性疾病中的黏膜变化通过体视显微镜、黏膜结构测量和乳糖利用减少来证明。上皮DNA丢失率的测量表明，与黏膜测量相关，结构变化是由上皮发育不全引起的。在因其他非恶性消耗性疾病导致严重体重减轻的患者中也有类似发现。虽然恶性疾病中无疑会发生黏膜变化，但这些变化并非恶性肿瘤所特有，“癌性肠病”的概念是站不住脚的。有人认为黏膜变化是恶病质的结果而非原因。
