The R&D Laboratory of the Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Gut Microbes. 2011 Sep 1;2(5):287-93. doi: 10.4161/gmic.2.5.18269.
Human beings live in symbiosis with billions of microorganisms colonizing mucosal surfaces. The understanding of the mechanisms underlying this fine-tuned intestinal balance has made significant processes during the last decades. We have recently demonstrated that the interaction of SIgA with Gram-positive bacteria is essentially based on Fab-independent, glycan-mediated recognition. Results obtained using mouse hybridoma- and colostrum-derived secretory IgA (SIgA) consistently show that N-glycans present on secretory component (SC) play a crucial role in the process. Natural coating may involve specific Gram-positive cell wall components, which may explain selective recognition at the molecular level. More widely, the existence of these complexes is involved in the modulation of intestinal epithelial cell (IEC) responses in vitro and the formation of intestinal biofilms. Thus, SIgA may act as one of the pillars in homeostatic maintenance of the microbiota in the gut, adding yet another facet to its multiple roles in the mucosal environment.
人类与数十亿定植于黏膜表面的微生物共生。在过去几十年中，人们对这一精细肠道平衡机制的理解取得了重大进展。我们最近证明，SIgA 与革兰氏阳性菌的相互作用主要基于 Fab 非依赖性、聚糖介导的识别。使用小鼠杂交瘤和初乳衍生的分泌型免疫球蛋白 A（SIgA）获得的结果一致表明，分泌成分（SC）上存在的 N-聚糖在该过程中起着关键作用。天然涂层可能涉及特定的革兰氏阳性细胞壁成分，这可以解释在分子水平上的选择性识别。更广泛地说，这些复合物的存在涉及体外调节肠道上皮细胞（IEC）的反应和肠道生物膜的形成。因此，SIgA 可能是维持肠道微生物群稳态的支柱之一，在黏膜环境中发挥其多种作用的基础上又增加了一个方面。
