Eker Furkan, Akdaşçi Emir, Duman Hatice, Yalçıntaş Yalçın Mert, Canbolat Ahmet Alperen, Kalkan Arda Erkan, Karav Sercan, Šamec Dunja
Department of Molecular Biology and Genetics, Çanakkale Onsekiz Mart University, Çanakkale 17000, Turkey.
Department of Food Technology, University North, Trg Dr. Žarka Dolinara 1, 48000 Koprivnica, Croatia.
Antibiotics (Basel). 2024 Mar 11;13(3):251. doi: 10.3390/antibiotics13030251.
The growing number of antibiotic resistance genes is putting a strain on the ecosystem and harming human health. In addition, consumers have developed a cautious attitude towards chemical preservatives. Colostrum and milk are excellent sources of antibacterial components that help to strengthen the immunity of the offspring and accelerate the maturation of the immune system. It is possible to study these important defenses of milk and colostrum, such as lactoferrin, lysozyme, immunoglobulins, oligosaccharides, etc., as biotherapeutic agents for the prevention and treatment of numerous infections caused by microbes. Each of these components has different mechanisms and interactions in various places. The compound's mechanisms of action determine where the antibacterial activity appears. The activation of the antibacterial activity of milk and colostrum compounds can start in the infant's mouth during lactation and continue in the gastrointestinal regions. These antibacterial properties possess potential for therapeutic uses. In order to discover new perspectives and methods for the treatment of bacterial infections, additional investigations of the mechanisms of action and potential complexes are required.
抗生素抗性基因数量的不断增加正给生态系统带来压力并损害人类健康。此外,消费者对化学防腐剂已持谨慎态度。初乳和牛奶是抗菌成分的优质来源,有助于增强后代免疫力并加速免疫系统成熟。研究牛奶和初乳的这些重要防御物质,如乳铁蛋白、溶菌酶、免疫球蛋白、寡糖等,作为预防和治疗由微生物引起的多种感染的生物治疗剂是可行的。这些成分中的每一种在不同部位都有不同的作用机制和相互作用。该化合物的作用机制决定了抗菌活性的出现位置。牛奶和初乳化合物抗菌活性的激活可在哺乳期间婴儿口腔中开始,并在胃肠道区域持续。这些抗菌特性具有治疗用途的潜力。为了发现治疗细菌感染的新观点和方法,需要对作用机制和潜在复合物进行更多研究。