乳腺中新型单能干细胞的揭示。
The unmasking of novel unipotent stem cells in the mammary gland.
机构信息
Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
出版信息
EMBO J. 2011 Nov 8;30(24):4858-9. doi: 10.1038/emboj.2011.415.
Abstract
Nature 479 7372, 189–193 (2011); published online October 09 2011 Mammary stem cells (MaSCs) have been prospectively isolated and shown to reconstitute a fully functional mammary gland in the mouse at the single cell level. These cells are self-renewing and can differentiate into all mature mammary epithelial cell types, thus fulfilling the defining characteristics of a stem cell. In a recent issue of , Blanpain and colleagues (Van Keymeulen et al, 2011) add a new layer of complexity to the prevailing model of the mammary epithelial hierarchy through the recognition of novel unipotent stem cells that appear to maintain normal homeostasis of postnatal mammary epithelium. These data point to the existence of an unexpectedly complex hierarchy of stem cells that include multipotent as well as more restricted stem cells.
摘要
《自然》479, 189–193 (2011); 在线出版 2011 年 10 月 9 日——乳腺干细胞（MaSCs）已被前瞻性分离出来，并在小鼠中在单细胞水平上证明可重建一个完全功能的乳腺。这些细胞具有自我更新能力，并能分化为所有成熟的乳腺上皮细胞类型，因此满足了干细胞的定义特征。在最近的一期《 》中，Blanpain 及其同事（Van Keymeulen 等人，2011 年）通过识别似乎维持出生后乳腺上皮正常内稳态的新型单能干细胞，为乳腺上皮层次结构的主流模型增添了新的复杂性。这些数据表明，存在着一种出乎意料的复杂的干细胞层次结构，其中包括多能干细胞和更受限的干细胞。
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